Physico-Chemical Properties of Drug-Additive Systems

ISBN-13: 9783847372851 / Angielski / Miękka / 2012 / 168 str.

Malik Abdul Rub;Kabir -Ud-Din

Opis

A most common challenge faced by pharmaceutical scientists as well as industry is to design and develop drugs with good aqueous solubility while simultaneously retaining potency and selectivity. This problem can be overpowered by the use of mixed micelles of drug-surfactant or surfactant-surfactant. The results would be helpful towards the development of drug formulations which will expectedly help in removing their disadvantages towards accumulation within bio-membranes. The amphiphilic drugs, because of their surfactant-like nature, exhibit concentration, temperature and pH-dependent phase separation (clouding), therefore, it is important to have knowledge of clouding behavior of the drugs in designing more effective drug-carrier combinations. With this idea in mind, effects of various additives, viz., electrolytes, non-electrolytes, alcohols, surfactants, sugars, and amino acids have been examined on clouding behavior of some amphiphilic drugs.

O autorze

Dr. Malik Abdul Rub completed his B.Sc.and M.Sc. from Aligarh Muslim University with the specialization in Industrial Chemistry and also completed his Ph.D. in 2011 from same university. He is currently working as an Assistant Professor in Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah-21589, Saudi Arabia.