Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation

ISBN-13: 9783319216867 / Angielski / Twarda / 2015 / 177 str.

Hector Eduardo Jardon-Valadez; Orlando Guzman-Lopez; Luis Olivares-Quiroz

Opis

This book covers the latest developments in the physical biology of proteins and peptides. Key insights into microscopic and macroscopic approaches to describe biologically relevant macromolecules and their interactions are provided. This book also covers a wide range of tools, including theoretical methods as statistical mechanics, normal mode analysis, kinetic theory and stochastic processes, and all-atom and coarse-grained molecular dynamics simulations. New experimental techniques are also discussed, particularly related to amiloidogenic peptides and their mutations. This is an excellent book for molecular biologists, physicists, computational scientists, and chemists. It covers cutting-edge research in this exciting, interdisciplinary research field.This book also: Discusses the latest developments in the physical biology of proteins, peptides and enzymes covering theoretical, computational, and experimental approachesBroadens readers' understanding on the role of intra- and inter-molecular interactions as a fundamental cornerstone of macroscopic biological properties of macromoleculesProvides a wide and useful perspective on different aspects of the physics, biology, and chemistry of proteins and peptides suitable for interdisciplinary research.

Spis treści

Chapter 1 The structural determinants of the immunoglobulin light chain amyloid aggregation.- Chapter 2 Thermodynamics and kinetics of amyloid aggregation from atomistic simulations.- Chapter 3 Determination of the size of the primary and secondary folding nuclei of protofibrils from the concentration dependence of the rate and the lag-time of their formation.- Chapter 4 Modulation of cholera toxin structure/function by Hsp90.- Chapter 5 Function, structure and stability of human gamma D crystallins: A review.- Chapter 6 Protein motions, dynamic effects and thermal stability in dihydrofolate reductase from the hyperthermophile Thermotoga maritime.- Chapter 7 Ab initio folding of glycophorin A and acetylcholine M2 transmembrane segments via simplified environment molecular simulations.- Chapter 8 Multi-scale approaches to dynamical transmission of protein allostery.- Chapter 9 Dynamics of membrane proteins and lipid bilayers.- Chapter 10 What makes a transcriptional master regulator? A systems biology approach.