Pharmacological Treatment of Chronic Stable Angina Pectoris

ISBN-13: 9783319173313 / Angielski / Miękka / 2015 / 278 str.

Pablo Avanzas; Juan Carlos Kaski

Opis

This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The goal of this book is to update clinicians on recent data on the medical management of patients with CSA. Ischemic heart disease remains a major public health problem. Chronic stable angina is the initial manifestation of ischemic heart disease in approximately one half of patients. Stable coronary artery disease is generally characterized by episodes of reversible myocardial demand/supply mismatch, related to ischaemia or hypoxia, which are usually inducible by exercise, emotion or other stress and reproducible but, which may also be occurring spontaneously. Such episodes of ischaemia/hypoxia are commonly associated with transient chest discomfort (angina pectoris). The aim of the management of CSA is to reduce symptoms and improve prognosis. The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education. All patients with stable angina should be offered optimal medical treatment, defined as one or two anti-anginal drugs as necessary, plus drugs for secondary prevention of cardiovascular disease. Regarding the role of revascularization, randomised trials provide compelling evidence that myocardial revascularisation by coronary artery bypass grafting or by percutaneous coronary intervention improves symptoms of angina relative to continued medical treatment."

Recenzje

"This comprehensive book discusses the various medical therapies available to manage angina pectoris. ... The book is aimed at a wide range of clinicians including medical students, interns, residents, general cardiologists, and interventional cardiologists. ... This book would be a valuable addition to the library of any cardiologist or aspiring cardiologist interested in the medical management of angina." (Arthur Menezes, Doody's Book Reviews, August, 2015)

Spis treści

​ Mechanisms of angina.- An overview of treatment and guidelines – ESC /ACC-AHA/ NICE.- Beta-blockers.- Calcium channel blockers.- Nitrates.- Nicorandil.- Ivabradine. Trimetazidine.- Ranolazine.- New antianginal drugs still not available for clinical use.- Medical therapy versus revascularization in the management of stable angina pectoris.

O autorze

Dr Pablo Avanzas is a Consultant in Interventional Cardiology at Hospital Universitario Central de Asturias in Oviedo, Spain. Dr Juan Carlos Kaski is Head of the Cardiovascular Sciences Research Centre at St George's University of London (UK) and President of the International Society of Cardiovascular Pharmacotherapy.

Blurb

This book describes the clinical challenge currently posed by stable angina pectoris and provides guidance for those making clinical decisions regarding its pharmacological treatment. The importance of providing effective treatment is beyond dispute and this book deals with the most relevant aspects related to its pharmacological treatment. The pathogenesis of myocardial ischemia as the basis for rational treatment of angina is discussed thoroughly together with all major management goals including optimal symptom control and the secondary prevention of serious cardiovascular events.

Pharmacological Treatment of Chronic Stable Angina Pectoris provides a clear description of the mechanisms of action and clinical indications of available anti-angina drugs and strategies for the use of novel pharmacological agents. It also includes a critical appraisal of the major management guidelines, which will assist the reader to interpret current evidence and provide the most appropriate forms of treatment. The ongoing controversy regarding medical therapy versus myocardial revascularization for the management of stable angina pectoris is also addressed.

This eminently practical book will help guiding the reader through the complexities of the field and will be highly appreciated by clinicians, clinical cardiologists and cardiology trainees alike.