Pathochemical Markers in Major Psychoses

ISBN-13: 9783642697456 / Angielski / Miękka / 2011 / 158 str.

H. Beckmann; P. Riederer; M. Ackenheil

Opis

This volume contains the proceedings of the symposium Pathochemical Markers in Major Psychoses, held in Vienna in July 1983. The development of biological markers in psychiatric diseases, par ticularly in the field of neurochemistry, has made substantial progress during recent years although the multiple mechanisms of mental illness are still not fully understood. The greatest contribution has come through the development of new therapeutic agents that not only pro vide invaluable help for psychiatric patients but also serve as chemical tools for the investigation of the biological mechanisms underlying the disease. The catecholamine and serotonin hypotheses for major psy choses have been of particular heuristic value and have stimulated im portant research. However, the scope of our scientific endeavours has to be broadened to include other putative biological causes of psychoses, e. g., pathomorphological changes, aberrations in the metabolism of other amino acids and oflipids, or the formation of endogenous toxins. This book presents new selected studies of the pathochemical bases of schizophrenia and affective psychoses. Although several topics were inevitably not included in this symposium, we nevertheless hope that it represents an integration of basic pathomorphological research with current clinical findings in the area of pathochemical markers in psy chiatry. October 1984 HELMUT BECKMANN PETER RIEDERER Contents Neuromorphological Background of Pathochemical Studies in Major Psychoses K. JELLINGER (With I Figure) . . . . . . . . . . of Psychopathological Classification The Significance in Interpreting Biochemical Findings E. GABRIEL . . . . . . . . . . . . . . . . ."

Spis treści

Neuromorphological Background of Pathochemical Studies in Major Psychoses.- The Significance of Psychopathological Classification in Interpreting Biochemical Findings.- Receptors, Neuroleptics and Dopamine Concentrations in Schizophrenia — Postmortem Studies of Human Brain Tissue.- Brain Biochemistry in Schizophrenia: An Assessment.- Biochemical Disturbances in Psychiatric Disorder: Are They Specific to Diagnosis or to Certain Symptoms?.- Further Studies on the Tyramine Conjugation Deficit in Depressive Illness.- Disturbances in Serine-Glycine Metabolism in Relation to Acute Psychoses with Psychedelic Symptoms.- Peptides and Amines in Affective Disorders.- Biochemical and Neuroendocrine Studies in Schizophrenics: Attempts to Characterize the Illness Biochemically.- Decreased Spinal Fluid Monoamine Metabolites and Norepinephrine in Schizophrenic Patients with Brain Atrophy.- The Use of Platelet Monoamine Oxidase in Multifactorial Research on Endogenous Psychoses.- Neuroendocrine Responses to Serotonin Agonists as Possible Markers of the Functional State of Serotonergic Neurotransmission in Psychiatric Disorders.- Cerebrospinal Fluid Amine Metabolite Studies in Depression: Research Update.- CSF Studies in Schizophrenia: A Multidimensional Approach.- Abbreviations.