Palladium(0)-Catalyzed Cross-Coupling and Cyclocondensations Reactions

ISBN-13: 9783639376494 / Angielski / Miękka / 2011 / 160 str.

Tung Thanh Dang

Opis

The main part of this book is the efficient regioselective synthesis of functionalized heterocycles (furans, pyrroles, thiophenes, selenophenes) based on the palladium(0)-catalyzed cross-coupling and metal-halide exchanged reactions of brominated heterocycles. The study of the efficient methodologies (regioselectivities, optimization of condition including catalysts, solvent, temperature ...) to functionalize them to give a valuable synthetic procedure for the synthesis of pharmacologically relevant products and of useful intermediates for further synthetic transformations. These simple methodologies were applied to synthesize the sulfur- analogues of pyrrole natural product, such as ningaline A. The second part is oriented synthesis of N,O-heterocycles. The convenient approach to synthesized pyrazole-3-carboxylates and pyrazole-1,5- dicarboxylates by one-pot cyclization of hydrazone dianions with diethyl oxalate and 6-iodo- and 6- bromomethyl-5,6-dihydro-4H-1,2-oxazines by condensation of dilithiated acetophenone-oximes with allylbromide and subsequent regioselective iodine- or NBS-mediated cyclization were shown.

O autorze

Dang Thanh Tung obtained his M.Sc. in chemistry at the Hanoi University of Sciences, Vietnam (2006) and his Dr. degree in the group of Prof. Peter Langer at the University of Rostock, Germany (2009). After studying with Prof. Rèmi Chauvin at Toulouse (2010), he joined the group of Prof. Valérie Heitz at the University of Strasbourg, France.