Oxygen Transport to Tissue--VI

ISBN-13: 9781468448979 / Angielski / Miękka / 2013 / 924 str.

Duane F. Bruley; Duane F. Bruley

Opis

The theme of the 1983 annual ISOTT meeting emphasizes a dual scientific approach, utilizing interdisciplinary theoretical and experimental methodology, to unravel the secrets of oxygen transport to tissue. ISOTT is leading the way in the development and application of forefront techniques to allow a more basic understanding of this important physiological phenomena. The Society can be proud of its contributions in helping to advance the gross analysis techniques of the past to the synergistic study of tissue micro areas by sophisticated mathematical and experimental means. There is a tremendous need to continue the pursuit of basic knowledge at the regional tissue level and to move rapidly to the examination of fundamental biochemical reactions at the cellular level. To accomplish this, it will be necessary to take advantage of the most powerful computing machinery presently available and to apply state-of-the-art experimental methodology, such as polarographic, autoradiographic and nuclear magnetic resonance techniques in our studies. Our Society must continue to work hard to push back barriers to enhance our understanding of mechanisms that lead to pathology. Hopefully, our efforts will be significant in helping science to overcome the many dreadful diseases that mankind faces in today's world. Duane Bruley Haim Bicher Daniel Reneau v ACKNOWLEDGEMENT We are forever indebted to Connie Staggs and Ellie Topakoglu for their energy and sacrifice in preparing for and managing the 1983 ISOTT meeting.

Spis treści

Distribution Of Blood Flow In Partially Closed Cerebral Capillary Networks.- Microcirculatory Mass Transfer.- Transients Of Gas Exchange Processes In The Upper Skin Calculated By The Capillary Loop Model.- Approximate-Analytical Solution Of The Diffusion, Convection And Reaction Problem In Homogeneous Media.- Elements For Modeling Inert Gas Washout From Heterogeneous Tissues.- Effects Of Modeling Assumptions On Oxygen Transport In Isolated Heart.- Dual Role Of Diffusion In Tissue Gas Exchange: Blood-Tissue Equilibration and Diffusion Shunt.- A Model of Transport and Metabolism in Neurons.- A Two Pore Size Distribution Model For Transcapillary Exchange Of Substances.- An Isolated Rat Brain Preparation Perfused With A Fluorocarbon Emulsion.- NAD Pools In The Brain Coretx Effect Of Reversible Anoxic-Anoxia And Irreversible Anoxic-Ischemia.- Perfused Canine Brain: Metabolism And Blood-Brain Transport During Altered Metabolic States.- Responses Of Gerbil Cerebral Unit Activity To Declining Tissue PO2.- Effect Of Lactate And Pyruvate On Cerebrocortical Microcirculation and NAD/NADH Redox State.- Cerebral Oxygen Utilization As A Gauge Of Brain Energy Metabolism.- Tissue Oxygenation In Normal And Edematous Brain Cortex During Arterial Hypocapnia.- Changes In Cerebral Oxygen Tension And Red Cell Content On Sensory Stimulation.- Brain Responses To Experimental Oxygen Deficiency In The Mongolian Gerbil.- Distribution Of Cerebrocortical Microflow In Normo- And Hypertensive Rats.- Noradrenergic Modulation Of Cerebral Cortical Oxidative Metabolism.- Mechanisms Of Brain Survival In Anoxia: Mitochondrial Activity And Ion Hemostasis In Turtle And Rat.- Computer Controlled Blood Pressure Changes Required For Steady State Oxygen Control Of Partial Ischemia In The Rat Brain Cortex.- Selective Anoxic Injury To Thick Ascending Limb: An Anginal Syndrome Of The Renal Medulla?.- An In-Vitro Method For Simulation Of Oxygen Transport In The Microcirculation.- Increased Resolution Power In Po2 Analysis At Lower Po2 Levels Via Sensitivity Enhanced Optical Po2 Sensors (Po2 Optodes) Using Fluorescence Dyes.- Mechanisms Of Thiol Reaction With Oxygen: Implications For Hyperthermic And Radiation Therapies.- Tumor Blood Flow and O2 Availability During Hemodilution.- Heterogeneous Oxygenation of Rectal Carcinomas In Humans: A Critical Parameter For Preoperative Irradiation?.- On The Mechanism For Enhancement Of Tumor Radiation to Hyperbaric Oxygen In Sodium Pentobarbital Anesthetized Rodents.- Oxygen Consumption And Oxygen Diffusion Properties Of Multicellular Spheroids From Two Different Cell Lines.- Control Of Oxygen Utilization In Vitro And In Vivo: Implications For Radiotherapy Of Tumors.- An Evaluation Of Easton’s Paradigm For The Oxyhemoglobin Equilibrium Curve.- Oxygen Affinity Of Hemoglobin Solutions Modified By Coupling To PLP Or NFPLP And The Effects On Tissue Oxygenation.- The Effect Of Blood O2 Affinity On The Efficiency Of O2 Transport In Blood At Hypoxic Hypoxia.- Secondary CO2 Diffusion Folowing HCO3- Shift Across The Red Cell Membrane.- Concepts Of Brain Oxygen Sufficiency During Seizures.- Determination Of Pulmonary Parameters (V?A, $$ {D_{{L_{{O^2}}}}} $$) From Arterial O2 and CO2 Partial Pressures During Exercise.- Effects Of Anaerobic Substrates On Post-Anoxic Cellular Functions In Isolated Tubular Segments Of Rat Kidney Cortex.- Oxygen Supply To The Myocardium.- Capillary Density In The Isolated Perfused Guinea Pig Heart During Normoxic and High-Flow Hypoxic Perfusion.- An Analytical Model For Axial Diffusion In The Krogh Cylinder.- Cold Protected Hearts Extract Oxygen From Fluosol-DA During Cardiopulmonary Bypass.- Direct Effects Of Oxygen Toxicity During The Cardiac “Oxygen Paradox”.- The Effect Of Cell Size And Capillary Spacing On Myocardial Oxygen Supply.- Effects Of Myocardial Ischemia On Cardiac Contractility And Ion Transport In Working And Langendorff Rabbit Heart.- Heart Rate and PO2 In The Fetal Lamb.- Michaelis-Menten-Like Kinetics In The Krogh Tissue Cylinder.- Importance Of Sanguineous Component Of Perfusate On Post Ischemic Contractile Function In The Isolated Rabbit Heart.- Implications Of Altered Hemoglobin Concentration With Variations In Oxygen Consumption, Arterial Oxygen Saturation, And Age Based On A Mathematical Model For The Utilization Of Reserve Oxygen Transport Capacity.- The Effects Of Mixing On Continuous Michaelis-Menten Reactions.- The Effect Of Myoglobin Concentration On Muscle Cell PO2 Gradients.- Augmentation And Facilitation Of Oxygen Transfer In Flowing Hemoglobin Solutions.- Analysis Of Tissue Reflection Spectra Obtained From Brain Or Heart, Using The Two Flux Theory For Non-Constant Light Scattering.- Skin Oxygen Diffusion Conductance In Premature Infants.- Tissue Oxygenation By Fluorocarbons.- Normal Values Of Oxygen Concentration In Human Blood.- O2 Transport And Uptake In Dogs During CO Hypoxia With And Without ?-Block.- The Hypoxic Response To Hypovolemia.- Dopamine Effects On The Oxygenation Of Human Skeletal Muscle.- Measurements Of Local PO2 In The Resting Skeletal Muscles Of Rats With Portocaval Anastomosis (PCA) Under Normoxic Conditions.- Dependence Of Cellular Metabolism And Local Oxygen Delivery On Oxygen Tension.- A Standardized ‘In Vivo’ Model For The Study Of Experimental Arterial Thrombosis: Description Of A Method.- Balance Between O2 Availability and V?O2 In Rest-Work Transition As Measured By Myoglobin Saturation In Subcellular Volumes.- Effects Of Glucose And Thiol Depletion On Chemically-Induced Peroxide Production In Mammalian Cells.- Enhancement Of P50 By Inositol Hexa Phosphate Entrapped In Resealed Erythrocytes In Piglets.- Circulatory Responses To Chemical Stimulation Of Oxygen Uptake In Canine Hindlimb.- Fast Local Regulations Of Muscle PO2-Fields In Patients Suffering From Cirrhosis Of The Liver.- Mitochondrial Distribution In Hamster Cremaster Muscle.- Neural And Transmitter Influence On The Capillary Diameter In Exteriorized Frog Mesentery.- Isolated Perfusion Of The Small Intestine Using Per-Fluorotributylamine As Artificial Oxygen Carrier.- Regional Glucose Consumption And Oxygen Supply In The Isolated Perfused Working Rat Heart.- Response Of Spinal Cord Oxygen Tension To Aortic Occlusion.- A Thermistor Device For The Continuous Recording Of Mass Transport Velocity In Tissue Based On The Heat Clearance Principle.- Compact CO2 Gas Analyzer With Favourable Signal-To-Noise Ratio And Resolution Using Special Fluorescence Sensors (OPTODES) Illuminated By Blue LED’s.- Effect Of H2 Receptor- And Muscarine Receptor Antagonists And Prostaglandin E1 Analog On The Gastric Mucosal Hemodynamics And Oxygen Sufficiency In Rats.- Direct Measurement Of Reoxygenation In Malignant Mammary Tumors After A Single Large Dose Of Irradiation.- Microcomputer Measurement Of Blood And Tissue Oxygenation.- The Effect Of Different Parameters (Temperature, O2 Consumption, Blood Flow, Hemoglobin Content) On The tcPO2 Calibration Curves Calculated By The Capillary Loop Model.- A Digital Model For Determining Oxygen Consumption In Tissue.- A Computerized Mathematical Model Of Arterial Thrombi Recorded By Light Transmission.- Perfluorinated Organic Liquids And Emulsions As Biocompatible NMR Imaging Agents For 19F And Dissolved Oxygen.- Lipid Peroxidation Effects On Isolated Rat Retina.- Cerebral Cortical Oxygenation And Perfusion During Hetastarch Hemodilution.- Regulation Of Local Cerebral Blood Flow.- A Microelectrode For Measuring Intracellular pH1.- A Simulation Of Three Dimensional Oxygen Transport In Brain Tissue With Single Neuron-Single Capillary System The Williford-Bruley Technique.- Changes in Tumor Tissue Oxygenation During Microwave Hyperthermia: Clinical Relevance.- Capillary Wall Permeability Effects in Perfused Capillary-Tissue Structures.