Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

ISBN-13: 9780367388782 / Angielski / Miękka / 2019 / 344 str.

Helmut Sies

Opis

This groundbreaking work offers a comprehensive view of the different components of metabolic stress and its association-and that of obesity-with oxidative stress and inflammation. It reports on cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes in obesity and type 2 diabetes. The book also addresses the molecular mechanisms inherent in the progression of metabolic stress and considers phenotypic perspectives, as well as dietary factors and micronutrients. This book encourages evidence-based nutritional and pharmacological therapies to attenuate the impact of obesity-induced insulin resistance and ensuing metabolic syndrome.

Spis treści

The Metabolic Syndrome Defined. The Metabolic Syndrome: The Question of Balance between the Pro-Inflammatory Effect of Macronutrients and the Anti-Inflammatory Effect of Insulin. The Role of Oxidative Stress in Diseases Associated with Overweight and Obesity. Metabolic Syndrome Due to Early Life Nutritional Modifications. Oxidative Stress and Antioxidants in Perinatal Period. Maternal Obesity, Glucose Intolerance, and Inflammation in Pregnancy. Obesity, Nutrigenomics, Metabolic Syndrome, and Type 2 Diabetes. Post-Prandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetes. Obesity and Inflammation: Implications for Atherosclerosis. Oligomeric Composition of Adiponectin and Obesity. Insulin-Stimulated Reactive Oxygen Species and Insulin Signal Transduction. Intracellular Signaling Pathways and Perixosome Proliferator-Activated Receptors in Vascular Health in Hypertension and in Diabetes. Role of Uncoupling Protein 2 in Pancreatic ß-Cell Function: Secretion and Survival. Nutritional Modulation of Inflammation in Metabolic Syndrome. Dietary Fatty Acids and Metabolic Syndrome. Lipid-Induced Death of Macrophages: Implication for Destabilization of Atherosclerotic Plaques. a-Lipoic Acid Prevents Diabetes Mellitus and Endothelial Dysfunction in Diabetes-Prone Obese Rats. Lipoic Acid Blocks Obesity through Reduced Food Intake, Enhanced Energy Expenditure, and Inhibited Adipocyte Differentiation. Effects of Conjugated Linoleic Acid and Lipoic Acid on Insulin Action in Insulin-Resistant Obese Zucker Rats. Trivalent Chromium Supplementation Inhibits Oxidative Stress, Protein Glycosylation, and Vascular Inflammation in High Glucose-Exposed Human Erythrocytes and Monocytes. Index.

O autorze

Lester Packer, Helmut Sies