Oligomerization in Health and Disease: Volume 117

ISBN-13: 9780123869319 / Angielski / Twarda / 2013 / 656 str.

Jesus Giraldo

Opis

This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

Recenzje

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Spis treści

Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization

1. Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization
2. Structural, Evolutionary and Assembly Principles of Protein Oligomerization
3. Physico-Chemical Principles of Protein Aggregation
4. Structural Aspects of Amyloid Formation

Section II. Oligomerization in Seven-Transmembrane Receptors

5. Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers
6. Challenges in the Development of Heteromer-GPCR-Based Drugs
7. Oligomerization of GPCRs in Health and Disease on "Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance"
8. G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders
9. Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse

Section III. Oligomerization in Ion Channels

10. Social Networking among Voltage-Gated Potassium Channels
11. Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy
12. Consequences of Dimerization of the Voltage Gated Proton Channel
13. Receptor Heteromeric Assembly, How it Works and Why it Matters - The Case of Ionotropic Glutamate Receptors

Section IV. Oligomerization in Enzymes

14. The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase
15. Oligomerization of Dynamin Superfamily Proteins in Health and Disease
16. Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications
17. Oligomerization in Endoplasmic Reticulum Stress Signaling

Section V. Oligomerization in Regulatory Proteins

18. Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity
19. Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease
20. Chemokine Oligomerization in Cell Signaling and Migration
21. Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking

O autorze

Dr.Jesús Giraldo currently teaches at Universitat Autònoma de Barcelona in Barcelona, Spain. Dr. Francisco Ciruela currently teaches at University of Barcelona, Barcelona, Spain.