Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors: Volume 169

ISBN-13: 9780128179291 / Angielski / Twarda / 2020 / 348 str.

Jesus Giraldo; Francisco Ciruela

Recenzje

"This is a very important book that covers protein oligomerization in health and disease and provides essential knowledge of the oligomeric protein biology, which is critical to allow pharmacologic interventions in diseases associated with oligomeric protein malfunction. This is a unique book dedicated to fully explaining all about protein oligomerization." --Doody

Spis treści

1. Fluorescence microscopy methods for the study of protein oligomerization Roberto Arturo Petazzi, Amit Koikkarah Aji and Salvatore Chiantia 2. Computational prediction and redesign of aberrant protein oligomerization Jaime Santos, Valentín Iglesias and Salvador Ventura 3. Porphobilinogen synthase: An equilibrium of different assemblies in human health Eileen K. Jaffe 4. Prediction and targeting of GPCR oligomer interfaces Carlos A.V. Barreto, Salete J. Baptista, António José Preto, Pedro Matos-Filipe, Joana Mourão, Rita Melo and Irina Moreira 5. Integrated structural modeling and super-resolution imaging resolve GPCR oligomers Francesca Fanelli, Aylin C. Hanyaloglu and Kim Jonas 6. Exploring functional consequences of GPCR oligomerization requires a different lens Kyla Bourque, Jace Jones-Tabah, Dominic Devost, Paul B.S. Clarke and Terence E. Hébert 7. Continuing challenges in targeting oligomeric GPCR-based drugs Joaquin Botta, Julia Appelhans and Peter J. McCormick 8. Adenosine A_2A-dopamine D₂ receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura and L. Francesco Agnati 9. Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action Faron-Górecka Agata, Kusmider Maciej, Solich Joanna, Górecki Andrzej and Dziedzicka-Wasylewska Marta 10. Oligomerization of G protein-coupled receptors: Still doubted? Sergi Ferré, Francisco Ciruela, Vicent Casadó and Leonardo Pardo