Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors: Volume 115

ISBN-13: 9780123945877 / Angielski / Twarda / 2013 / 488 str.

Terry Kenakin

Opis

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

Recenzje

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Spis treści

1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors

Michael T. Klein, Paige N. Vinson and Colleen M. Niswender

2. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders

Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender

3. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery

Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis

4. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design

Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri

5. GPCRs in Stem Cell Function

Van A. Doze and Dianne M. Perez

6. Application of Receptor Theory to Allosteric Modulation of Receptors

David A. Hall

7. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors

Frederick J. Ehlert

8. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors

Jesús Giraldo

9. Chemokine Receptor Oligomerization and Allostery

Bryan Stephens and Tracy M. Handel

10. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

O autorze

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.