Novel Therapeutic Approaches to the Treatment of Parkinson's Disease: An Overview and Update

ISBN-13: 9783319399249 / Angielski / Twarda / 2016 / 151 str.

Corey R. Hopkins

Recenzje

"This book will be of most interest to chemists and medicinal chemists who are involved in the development of drugs for the treatment of Parkinson's disease, as well as other scientists involved in the drug discovery process. ... This is a timely and important overview for scientists involved in drug discovery of new therapies for the treatment as well as the slowing of progression of Parkinson's disease." (Thomas L. Pazdernik, Doody's Book Reviews, August, 2016)

Spis treści

Adenosine A2A Receptor Antagonists.- Targeting α-Synuclein as a Parkinson’s Disease Therapeutic.- Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.

Blurb

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.