Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases

ISBN-13: 9789400727731 / Angielski / Twarda / 2012 / 568 str.

Rahimi, Farid

Opis

Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems.

Spis treści

Preface

1. Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins; Farid Rahimi and Gal Bitan

2. Pathologic Lesions in Alzheimer disease and Other Neurodegenerative Diseases—Cellular and Molecular Components; Harry V. Vinters, Spencer Tung, and Orestes E. Solis

3. Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins; Anat Frydman-Marom, Yaron Bram, and Ehud Gazit

4. Biological Targeting and Activity of Pre-fibrillar Aβ Assemblies; Kyle C. Wilcox, Jason Pitt, Adriano Sebollela, Helen Martirosova, Pascale N. Lacor, and William L. Klein

5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s disease; Kiran Bhaskar and Bruce T. Lamb

6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease; Dong-Pyo Hong, Wenbo Zhou, Aaron Santner³, and Vladimir N. Uversky

7. Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM); Theri L. Degaki, Dahabada H. J. Lopes, and Mari C. Sogayar

8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis; Aaron Kerman and Avijit Chakrabartty

9. Structural Studies of Prion Proteins and Prions; Giuseppe Legname, Gabriele Giachin, Federico Benetti

10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies; Rodrigo Morales, Claudia A. Duran-Aniotz, and Claudio Soto

11. When More Is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease; Regina M. Murphy, Robert H. Walters, Matthew D. Tobelmann, and Joseph P. Bernacki

12. Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis; John P. Hodkinson, Alison E. Ashcroft, Sheena E. Radford

13. Transthyretin Aggregation and Toxicity; Maria J. Saraiva, Isabel S. Cardoso

14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases; Jennifer D. Lanning and Stephen C. Meredith

Blurb

Aberrant protein folding and self-assembly underlie over 30 human diseases called amyloidoses, for which currently there is no cure. The diseases range from tissue-specific to systemic and from genetic to sporadic. Some of the most devastating amyloidoses are those that affect the central nervous system (CNS), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), prionoses (e.g., mad-cow disease), and amyotrophic lateral sclerosis (Lou Gehrig’s disease). In each disease, one or more proteins self-associate into toxic oligomers that disrupt cellular function and communication, and proceed to form insoluble amyloid aggregates characterized by fibrillar morphology and cross-β structure.

The first decade of the 21^st century has brought with it significant progress in our understanding of amyloid diseases, including the physiological and pathological processes involving each of the offending proteins. Important developments also provide now improved diagnoses of different amyloidoses and new approaches are being developed towards disease-modifying therapies. This book covers the current state-of-the-art knowledge on amyloidoses as a general phenomenon and offers detailed reviews of individual amyloid-forming proteins and specific diseases.

Features:

• Coverage of the pathologic and pathogenic structures of amyloidogenic proteins from the pathological lesions to the evasive oligomers that are believed to be the main culprits.
• Detailed discussions of diseases of epidemic proportion, such as Alzheimer’s disease, Parkinson’s disease, and type-2 diabetes.
Current reviews of multiple diseases, including amyotrophic lateral sclerosis, prionoses, expanded polyglutamine diseases, dialysis-related amyloidosis, and transthyretin-related amyloidoses.
• Mechanism-based strategies for inhibiting protein aggregation and potential therapeutic applications in different diseases.