Non-Clinical Vascular Infusion Technology, Volume I: The Science

ISBN-13: 9781439874493 / Angielski / Twarda / 2013 / 216 str.

Owen P. Green; Guy Healing

Opis

With the evolution of vascular infusion technology, its use in the preclinical safety assessment of pharmaceuticals has become increasingly widespread. Hence, a need has developed for a single source on the scientific principles behind this technology. A logical companion to the new edition of The Techniques of Non-Clinical Vascular Infusion Technology, this book brings together current knowledge and underlying practices from around the world to help refine the procedures and enhance the global understanding of infusion technology.

Recenzje

"Good science and good welfare go hand in hand. Innovative science and technology can be used to improve animal welfare. Equally, the 3Rs (replacement, refinement and reduction of animals in research) can provide fresh insight and novel approaches to advance science. By sharing data, knowledge and experience on the science behind infusion models and the refinement of the techniques used, there is the potential to have a significant impact on the 3Rs.

Owen Green and Guy Healing have shown the importance of the 3Rs in infusion technology at international meetings and in producing this book. The book will enhance uptake of the latest science behind vascular delivery systems to get better data and help influence decisions around the most appropriate model. It will also contribute to preventing repetition of method development and optimising experiments to answer specific scientific questions with the least impact on animals.

As in other areas of science, the field of infusion technology is constantly evolving. This edition of Non-Clinical Vascular Infusion Technology reviews current developments in the field that will support scientists in putting the 3Rs into practice."

—From the Foreword by Kathryn Chapman, Head of Innovation and Translation, the National Centre for the Replacement, Refinement and Reduction of Animals in Research

Spis treści

Body Fluid Dynamics. Introduction. Composition and units of measurement. Compartmentalization and Distribution. Movement between Compartments/Exchange. Body Fluid Homeostasis. Summary. References. Physico-Chemical Factors. Introduction. Osmolality. Acid-Base Balance. Viscosity. Surface Tension. Diffusion. Summary of Infusion Forces. References. Vascular Infusion Dynamics. Essential physiology. Intravenous Delivery Rates and Volumes. References. Formulation Considerations. Introduction. Formulation selection strategy. Study design and species/strain. The properties of the compound. Strategies for dealing with poor solubility. Unwanted formulation effects. Excipient toxicity. Strategies for dealing with injection site reactions and haemolysis. Strategies for dealing with poor stability. Sterility. Conclusion. References. Prestudy analytical assessments: Equipment compatibility. Stability of the formulation with the formulation storage vessel. Compatibility. Choice of material. References. Haemocompatibility. Introduction. Objectives. Methods of assessing haemocompatibility. Discussion. Conclusion. References. Annex: Common excipients and vehicles.