Nitric Oxide: Biology and Pathobiology

ISBN-13: 9780123738660 / Angielski / Twarda / 2009 / 845 str.

Opis

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

• Edited by Nobel Laureate Louis J. Ignarro

• Up-to-date therapeutic implications of nitric oxide research
• Authored by world experts on nitric oxide
• Detailed research of the biochemistry and synthesis of nitric oxide

Spis treści

Section I. Chemical Biology

Chapter 1

Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes

Chapter 2

Nitric oxide redox biochemistry in lipid environments

Chapter 3

Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration

Chapter 4

Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes

Section II. Principles of Biology

A. Nitric Oxide Synthases

Chapter 5

Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal

Chapter 6

Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases

Chapter 7

Regulation of the expression of inducible nitric oxide synthase

Chapter 8

Molecular Regulation of Inducible Nitric Oxide Synthase

B. Guanylate Cyclase and Cyclic GMP

Chapter 9

Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation

C. Nitric Oxide Signaling

Chapter 10

Untargeted Discovery of NO-modified Proteins 

Chapter 11

Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids

Chapter 12

Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1

Chapter 13

The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide

D. Regulation of Nitric Oxide Production

Chapter 14

Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence

E. Nitric Oxide and Remodeling

Chapter 15

The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies

F. Nitrite and Nitrate

Chapter 16

NO formation from inorganic nitrate and nitrite

Chapter 17

Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential

Chapter 18

Nitrite Therapy for Ischemic Syndromes

Chapter 19

Nitrite and heme globins: Reaction mechanisms and physiological targets

Section III. Principles of Pathobiology

A. Nitric Oxide and Cardiovascular Function

Chapter 20

Nitric Oxide in Vascular Damage and Regeneration

Chapter 21

Free radicals as atherosclerotic risk-The relation of NO-

Chapter 22

The role of oxidative stress in endothelial dysfunction and vascular inflammation

B. Pathophysiological Mechanisms of Nitric Oxide

Chapter 23

Nitric oxide, oxidative stress, immune response and critical care

Chapter 24

Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury

Chapter 25

Nitric oxide in airway inflammation

Chapter 26

Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance

O autorze

Louis J Ignarro is the Recipient of the 1998 Nobel Prize in Physiology or Medicine for demonstrating the signaling properties of nitric oxide. He is presently a Professor Emeritus at the Centre for Health Sciences, UCLA. His various other accolades include the 1998 Basic Research Price of the American Heart Association membership of the National Academy of Sciences, membership of the American Academy of Arts and Sciences, American Heart Association Distinguished Scientist, 2008, founder of the Nitric Oxide Society, founder and Editor-in-Chief of Nitric Oxide Biology and Chemistry, and notoriously the 'Father of Viagra'.