New epitome of human red blood cell destruction

ISBN-13: 9783659531989 / Angielski / Miękka / 2014 / 100 str.

Sugawara Yoshiaki

Opis

Human erythrocytes survive in the circulation for about 120 days. How do they appreciate aging and determine their lifespan? The objective of this monograph is to present a fully new compendium (molecular-sensing) of Heinz body formation mechanisms inherent in human erythrocytes, whereby α1-β1 (and α2-β2) interface of the hemoglobin molecule (α2β2) controls removal of erythrocytes from the blood circulation by triggering degradation of the molecule to hemichrome, and subsequent clustering of Heinz bodies within the erythrocytes depending on the internal and extraneous conditions of the erythrocyte. So, Heinz body-containing red cells become trapped in the spleen and undergo hemolysis.

O autorze

Yoshiaki Sugawara was born in Japan in 1951. He started his academic career in 1982 at the Department of Physiology, Hamamatu University, School of Medicine. From 1983 to 1985, he worked with L. J. Berliner at the Department of Chemistry, Ohio State University. He has been a professor of Physiology, Prefectural University of Hiroshima since 2005.