New Mechanisms for Tissue-Selective Estrogen-Free Contraception

ISBN-13: 9783540230892 / Angielski / Twarda / 2005 / 266 str.

H. B. Croxatto

Opis

Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.

Spis treści

Progesterone Receptors and Opportunities for Contraception.- Reproductive Tissue-Selective Actions of Progesterone Receptors.- The Progesterone Receptor/Estradiol Receptor Association and the Progestin-Triggered S-Phase Entry.- Endometrial Morphology and Progestogens.- Role of Progesterone in the Structural and Biochemical Remodeling of the Primate Endometrium.- Effects of Progestogens on Endometrial Maturation in the Implantation Phase.- Gene Expression During the Implantation Window: Microarray Analysis of Human Endometrial Samples.- Role of EBAF/Lefty in Implantation and Uterine Bleeding.- Mechanisms Underlying Menstrual Bleeding Disturbances with Progestogens.- Human Endocervical Mucins.- Fallopian Tube Physiology: Preliminaries to Monospermic Fertilization and Cellular Events Post-fertilization.