Preface Montserrat Diéguez, Mónica Helvia Pérez-Temprano and Eva Hevia 1. Carbanion-functionalized phosphines: New design elements for catalyst development Ilja Rodstein and Viktoria H. Gessner 2. Overview of outer-sphere electron transfer mediators for electrosynthesis Luana Cardinale, Shannon S. Stahl, Dipannita Kalyani and Dan Lehnherr 3. Boronic acids as additives in organic synthesis and catalysis Nir Ashrov and Anat Milo 4. Design of ruthenium nanoparticles for better performance in catalysis Nuria Romero, Rosa Axet and Karine Philippot 5. Computational design of industrially relevant enzymes Sílvia Osuna