New HPLC methods for quality control of tetracycline antibiotics

ISBN-13: 9783639268416 / Angielski / Miękka / 2010 / 180 str.

Naeem Khan

Opis

Tetracycline antibiotics are at climax for their clinical use all over. Some members of this group may cause kidney problems due to degradation.This resource book is essentially learning,invaluable and unique covering almost all core material in a versatile manner, necessary to provide an understanding of chemistry and new analytical techniques for Q.C of tetracyclines,their impurities & degradation products by HPLC. The book also provides key guidance on the preparation of epimers and degradation products of major tetracyclines.It is a desperate need of the Q.C laboratories, pharmaceutical industries and academic institutions.This book provides a new metric of success in quantitation of antibiotics purity. The major compounds from tetracycline group are doxycycline, oxytetracycline, tetracycline and chlortetracycline which are identified, separated and micro-quantitated very efficiently with related compounds in a reasonable time. Consequently,this book is of particular interest who might be considering a future carrier in research & development,in the pharmaceutical industries,in Q.C laboratories & as an academic professional.

O autorze

Naeem Hasan Khan,Professor & Head, Department of Pharmaceutical Chemistry,Aimst University,Malaysia,specialized in instrumental analysis of drugs. He is a registered pharmacist and holds Ph.D.from Belgium. The analytical methods developed by him for tetracycline group by H.P.L.C. are the official methods of U.S.P.and European Pharmacopoeia.