New Approaches of Protein Function Prediction from Protein Interaction Networks

ISBN-13: 9780128098141 / Angielski / Miękka / 2017 / 124 str.

Jingyu Hou

Opis

New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction.

• Provides innovative approaches and new developments targeting key issues in protein function prediction
• Presents heuristic ideas for further research in this challenging area

Spis treści

1. Introduction 2. Reliability of Protein Interactions 3. Clustering-Based Protein Function Prediction 4. Iterative Approaches of Protein Function Prediction 5. Functional Aggregation for Protein Function Prediction 6. Searching for Domains for Protein Function Prediction 7. Protein Function Prediction from Functional Connectivity 8. Conclusions

O autorze

Dr. Jingyu Hou has been undertaking research in bioinformatics, especially in protein function prediction from protein-protein interaction (PPI) networks for many years. Dr Hou is part of a strong bioinformatics research team from Deakin University in Australia and has published many high quality journal and international conference papers. Particularly for protein function prediction, Jingyu's research team has proposed and published various innovative algorithms to dynamically predict protein functions from PPI networks. These algorithms refer to many critical aspects of protein function prediction, including semantic similarities of proteins, dynamic selection of prediction domains, iterative function predictions and so on which are advanced and interesting in this area.