Neurotoxicology

ISBN-13: 9781420054873 / Angielski / Twarda / 2010 / 334 str.

G. Jean Harry; Hugh A. Tilson

Opis

This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson's or Alzheimer's disease. It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process.

Spis treści

Neuromorphology – Qualitative vs Quantitative. Blood-Brain Barrier – Maturation and Vulnerability. Behavior Principles and Phenotyping of Mice: Development and Adult Life Stages. Endocrine Disruption and Senescence: Altered Neural Function. Thyroid Hormone – Impact on the Developing and Adult Brain. The Immune System – Neuroprotective and Neurodestructive Roles. Adult Neurogenesis – Potential Target Site or Confounder for Neurotoxicity. Network Analysis Using Microarray Data to Identify Pathways. Oxidative Stress and Free Radicals – Translation of In Vitro to In Vivo. Identified Modes of Action for Neurotoxicity – Use of Alternate Model System to Address Specific Mechanistic Based Hypotheses. Biological Processes of Cell Death – Apoptosis, Necrosis, Autophagy Neurotoxins – The Fine Line Between Damage and Therapeutic Effects. The Inclusion of Epidemiological Data into the Evaluation of Human Health Risk For Neurological Effects. Susceptible Populations – Rationale, Identification, Risk Assessment. Principles and Practices of Childhood Neurodevelopment Assessments. Assessment of Adult Neurotoxicity – Exposure vs Disease Based In Vivo Brain Imaging.