Neuroinflammation -- From Bench to Bedside

ISBN-13: 9783540430902 / Angielski / Twarda / 2002 / 238 str.

Springer-Verlag; H. Kettenmann; G. a. Burton

Opis

Introducing neuroinflammation and its involvement in human neurodegenerative disease, this text discusses the microglia and their response to brain injury, the importance of the chemokine family, experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and MS.

Spis treści

1 Cellular Components of Neuroinflammation — An Introduction.- 2 Microglia and the Response to Brain Injury.- 3 Elucidating Molecular Mechanisms of Alzheimer’s Disease in Microglial Cultures.- 4 Neuronal SLC (CCL21) Expression: Implications for Neuron—Microglial Signaling System.- 5 Cytokine-Mediated Inflammation and Other Actions in the Central Nervous System.- 6 BSE, Scrapie, and vCJD: Infectious Neurodegenerative Diseases.- 7 Activated Microglia in Alzheimer’s Disease and Stroke.- 8 Inflammation in Stroke — A Potential Target for Neuroprotection?.- 9 Neuroinflammation in Alzheimer’s Disease: Potential Targets for Disease-Modifying Drugs.- 10 The Concept of In Vivo Imaging of Neuroinflammation with [11C](R)-PK11195 PET.- 11 Chemokine Receptors on Mononuclear Phagocytes in the Central Nervous System of Patients with Multiple Sclerosis.- 12 The Role of Apoptosis in Neuroinflammation.- Previous Volumes Published in This Series.

Blurb

Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied in this area, that novel therapeutic targets will be identified which will allow successful therapeutic intervention in a variety of neurodegenerative diseases.