Naturally Occurring Benzodiazepines, Endozepines, and Their Receptors: Implications for Benzodiazepine Therapy and Withdrawal

ISBN-13: 9780367409067 / Angielski / Miękka / 2021 / 202 str.

Robert B. Raffa; Diana Amantea

Opis

Understanding and addressing the current opioid crisis requires knowledge of the endogenous opioids (endorphins and enkephalins), but there is now evidence for a benzodiazepine crisis. Are there endogenous benzodiazepine-like substances – and what do they do? How do they affect the anti-anxiety drugs and their adverse effects?

Spis treści

1 Introduction  2 Benzodiazepines and Related Substances: Chemistry  3 Central Benzodiazepine Receptors: Structure and Function  4 Benzodiazepines and Related Substances: Therapeutic Uses and Problems  5 Peripheral Benzodiazepine Receptors  6 The search for Endogenous Benzodiazepines in Humans  7 Evidence for Presence in Non-human Animals  8 Biologically Active Phytochemicals Having Benzodiazepine-like Actions  9 Benzodiazepines, Flavonoids and GABA  10 The Microbiome and Benzodiazepines: A Connection?  11 Anxiety, Sleep, and Benzodiazepines  12 The Effects of Benzodiazepines on Memory  13 Naturally Occurring and Exogenous Benzodiazepines in Epilepsy: An Update  14 Impact of Endogenous Benzodiazepines on Tolerance, Abuse, or Withdrawal