Nanoparticles, to enhance bioavailability of anti-diabetic drug : Preparation and method development of Pioglitazone HCl loaded polymeric nanoparticles

ISBN-13: 9783659459917 / Angielski / Miękka / 2013 / 52 str.

Kuldeep Joshi; Bhoomika Joshi; Shobhana Menon

Opis

In this book stable nanoparticles of pioglitazone HCL were prepared using biodegradable polymer, to increases bioavailability and to control release of drug. PGZ is used for the treatment of diabetes mellitus type 2. The drug modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscular tissues and in the liver. It is an activator of the intracellular peroxisome proliferator-activated receptor- , and decreases metabolic and vascular insulin resistance causing rise in HDL-cholesterol plasma in humans. However, the poor aqueous solubility of PGZ may cause low bio absorption and limited therapeutic efficacy. So, the aim of the present study was to prepare stable PGZ loaded polymeric nanoparticles, to enhance the solubility and improve the bioavailability of the drug.

O autorze

Dr. Kuldeep Joshi earned his PhD in Chemistry from Prof. S.K. Menon at Gujarat University. He is currently working as an Assistant Prof. in KSV University. He published many research papers in various international journals. He actively involved in research area of Synthesis of nanomaterials by various chemical methods and its applications.