Nanomedicine for tuberculosis: Insights from pre-clinical studies

ISBN-13: 9783659341601 / Angielski / Miękka / 2015 / 100 str.

Parry Zahoor Ahmad

Opis

In spite of the availability of multi-bullet effective chemotherapy and BCG vaccine, tuberculosis is leading infectious killer globally. TB kills about 2 million people per year. At present, approximately one-third of the worlds population is infected with Mycobacterium tuberculosis and new infections occur @ one individual per second. There are several reasons that are responsible for such havoc despite the multidrug regimens. These include drug resistance, development of latency, patient non-compliance, delay in diagnosis, variable efficacy of BCG vaccine and co-infection with HIV etc.The present work discusses efforts that were made to evaluate azole antifungal drugs against tuberculosis especially drug resistant and persistent forms. Importantly nanomedicine efforts including chemotherapeutic potential of orally administered alginate nanoparticle encapsulated azole and antitubercular drugs against experimental tuberculosis along with direct nebulization of nano-formulation to lungs is thoroughly discussed.

O autorze

Dr. Z A Parry received Ph.D. from PGIMER Chandigarh India and latter had his post doctoral studies in CSIR-South Africa and Johns Hopkins University, School of Medicine Baltiomore USA. His studies have focused on nanotechnology based drug delivery, discovery and development of new antituberculosis drugs/regimens and development of new animal models.