Myocardial Failure: International Symposium, Rottach-Egern/Tegernsee, Germany, June 17-19, 1976

ISBN-13: 9783540082255 / Angielski / Miękka / 1977 / 374 str.

G. Riecker; A. Weber; J. Goodwin

Opis

More than 10 years have passed since the memorable symposium on "Myocardial Contractility," edited by R. D. Tanz, F. Kavaler and J. Roberts (New York and London, Academic Press, 1967). PathogeneSis of myocardial failure still involves many questions. The latest scien tific findings on fundamentals of myocardial contraction encouraged us to organize this international symposium held in Rottach-Egern at Tegernsee (Germany), June 17 to 19, 1976 sponsored by the European Society of Cardio ogy. It seemed appropriate to assemble prominent workers in this field in an attempt to correlate their respective in formation on cardiac function. In this connection it must be remembered that our present understand ing of the cardiovascular system and today's therapeutic and preventive measures are the fruits of yesterday's research. Further progress in this field will be conditioned by various circumstances: to win highly motivated creative people for clinical research, to mediate time and contacts for their learning new methods, and to provide adequate faci lities for scientific work in our hospitals. Therefore, the aim of the conference was to discuss those aspects of myocardial failure, that are believed to require further studies in the future by integrated efforts of research workers in several disciplines, especially to promote the pertinent exchange of ideas between basic and clinical research."

Spis treści

Session I. Molecular Basis of Myocardial Function.- 1. Regulatory and Contractile Proteins.- Introductory Remarks.- The Structural Basis of Contraction in Muscle and Its Study by Rapid X-Ray Diffraction Methods.- The Myosin Cross-Bridge as Revealed by Structure Studies.- Myosin-Linked Regulation: A Chemical Approach.- Myocardial Cross-Bridge Activity and Its Regulation by Ca++, Phosphate and Stretch.- Myosin Characteristics and Immunological Properties of Myocardial Tissue.- Concluding Remarks.- 2. Sarcoplasmatic Reticulum.- Introductory Remarks.- Relation of Calcium Permeability to the Ca++ Concentration Gradient Across the Sarcoplasmic Reticulum.- Calcium Binding and Cardiac Myofibril Activation.- Cyclic Nucleotides and Cardiac Contractility.- 3. Membrane-Bound Receptors.- Introductory Remarks.- Biochemical Characteristics of the Sodium Pump: Indications for a Half-of-Sites Reactivity of (Na+ + K+)-ATPase.- Receptor for Cardiac Glycosides.- Adenylate Cyclase Regulation and ?-Adrenergic Receptors in Guinea-Pig Myocardial Tissue.- The Role of the Mitochondrial Adenine Nucleotide Transport in Heart.- Session II. Clinical Aspects of Myocardial Failure.- 1. New Diagnostic Procedures.- Introductory Remarks.- Myocardial Biopsy Techniques.- Cellular and Subcellular Morphology of Biopsy Material.- Ultrastructure of Degenerated Muscle Cells in Patients With Cardiac Hypertrophy.- Humoral and Cellular Studies in Diseases With Heart-Reactive Antibodies.- Relationship Between Pulmonary Artery Pressure and Echocardiographic Mitral Valve Closure in Patients With Acute Myocardial Infarction.- Echocardiographic Evaluation of Myocardial Performance During Infusion of Angiotensin and Handgrip-Exercise.- 2. Problems of Etiology and Classification.- Introductory Remarks.- Classification and Natural History of Primary Cardiomyopathies.- Myocardial Lesions in Cardiomyopathies.- Cardiomyopathies Related to Immunological Processes.- Metabolic Heart Disease With Special Reference to Carbohydrate Metabolism in Health and Disease.- Session III. Clinical Pharmacology.- 1. Usefulness of Cardioactive Agents.- Introductory Remarks.- Contraction and Relaxation of Heart Muscle as Influenced by cAMP, Isoproterenol, Glucagon, Ouabain, and Calcium.- Direct Effects of Diuretic Drugs on the Myocardium.- Circulatory and Contractile Effects of Thyroid Hormones.- 2. Drugs Influencing Myocardial Contractility.- Introductory Remarks.- On the Inotropic and Arrhythmogenic Effects of Digitalis.- Beta-Blockers in Myocardial Failure.- The Hemodynamic Effects of Antiarrhythmic Drugs on the Depressed Myocardium.