Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives

ISBN-13: 9786206151517 / Angielski / Miękka / 56 str.

Dhaval B. Patel

Opis

A simple, versatile, one-pot, multi-component reaction (MCR) of ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives has been achieved in the presence of urea as a potent catalyst in water-ethanol as a green solvent system. Reaction was proceeding via three component reaction by utilizing various aldehyde, malononitrile and ethylacetoacetate at room temperature. All Synthesized products were confirmed by Mass, 1H-NMR, IR and Melting point. Mild reaction conditions, excellent yields, easy isolation of products, no column chromatographic separation, reusability of reaction media.

O autorze

Dhaval Patel is working in the chemistry field including synthesis, method development, computational chemistry and biologicals activity.