Multi-Drug Resistance in Cancer

ISBN-13: 9781607614159 / Angielski / Twarda / 2009 / 506 str.

Jun Zhou

Opis

Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .

Recenzje

From the reviews:

"This book uses cancer as the focus to discuss both the mechanistic events causing multi-drug resistance and the potential ways to mitigate it. ... In summary, this book provides a good overview of the development and treatment of multi-drug resistance in cancer. ... each individual chapter covers a specific area in an easy-to-read manner, which should leave the reader with a better understanding of the topic." (Nick Plant, BTS Newsletter, Issue 37, Winter, 2010)

"The topics covered in this 21-chapter volume have been provided by leading experts in the field. ... The chapters are generally well written and clear. ... This provides a full picture on what is going on in this exciting field. ... this book offers a comprehensive survey of the fields of knowledge and research concerning cancer multi-drug resistance mechanisms and reversal strategies. In this way, it is relevant for basic and clinical investigators, for the less experienced and mature researchers ... ." (Rolf W. Hartmann, ChemMedChem, Vol. 6 (3), 2011)

Spis treści

1. Multidrug Resistance in Cancer Bruce C. Baguley 2. Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets Wouter B. Nagengast, Thijs H. Oude Munnink, Eli C.F. Dijkers, Geke A.P. Hospers, Adrienne H. Brouwers, Carolien P. Schröder, Marjolijn Lub-de Hooge, and Elisabeth G.E. de Vries 3. Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer Sven Rottenberg, Marina Pajic, and Jos Jonkers 4. Mechanisms of Multidrug Resistance in Cancer Jean-Pierre Gillet and Michael M. Gottesman 5. Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells Anna Maria Calcagno and Suresh V. Ambudkar 6. Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical Implications Ingolf Cascorbi and Sierk Haenisch 7. Flow Cytometric Evaluation of Multidrug Resistance Proteins Adorjan Aszalos and Barbara J. Taylor 8. Targeted Chemotherapy in Drug Resistant Tumors and Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer Jothilingam Sivapackiam, Seth T. Gammon, Scott E. Harpstrite, and Vijay Sharma 9. Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing Emma K. Baker and Assam El-Osta 10. Expression and Function of P-Glycoprotein in Normal Tissues: Effect on Pharmacokinetics Frantisek Staud, Martina Ceckova, Stanislav Micuda, and Petr Pavek 11. Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1 Xiu-bao Chang 12. Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes Douglas D. Ross and Takeo Nakanishi 13. Drug Ratio-Dependent Antagonism: A NewCategory of Multidrug Resistance and Strategies for Its Circumvention Troy O. Harasym, Barry D. Liboiron, and Lawrence D. Mayer 14. Reversing Agents for ATP-Binding Cassette Drug Transporters Chow H. Lee 15. Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors Helen M. Coley 16. Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation Jeannie M. Padowski and Gary M. Pollack 17. Examination of CYP3A and P-Glycoprotein-Mediated Drug-Drug Interactions Using Animal Models Punit H. Marathe and A. David Rodrigues 18. Generating Inhibitors of P-Glycoprotein: Where to, Now? Emily Crowley, Christopher A. McDevitt, and Richard Callaghan 19. Immunosuppressors as Multidrug Resistance Reversal Agents Hamid Morjani and Claudie Madoulet 20. Overcoming Multidrug Resistance by RNA Interference Alexandra Stege, Andrea Krühn, and Hermann Lage 21. Circumventing Tumor Resistance to Chemotherapy by Nanotechnology Xing-Jie Liang, Chunying Chen, Yuliang Zhao, and Paul C. Wang

Blurb

With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein, to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The extensive volume also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression, as well as techniques for detection and imaging of drug transporters, methods for investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, Multi-Drug Resistance in Cancer offers a state-of-art collection of reviews and methods for both basic and clinician investigators who are interested in the vital study of cancer multi-drug resistance mechanisms and reversal strategies.