Mononuclear Phagocytes: Characteristics, Physiology and Function

ISBN-13: 9789401087230 / Angielski / Miękka / 2011 / 830 str.

R. Furth

Opis

Sixteen years have passed since the first Leiden Conference on Mononuclear Phagocytes. That first meeting led to new nomenclature, i. e., the Mononuclear Phagocytes System (MPS), which was published in the Bulletin of the World Health Organization (R. van Furth, et aI., Bull. WHO, 1972, 46: 845-852). The paradigm of the MPS has the advantage of being much more consistent than the Reticuloendothelial System (RES) (L. Aschoff, Ergebn. Inn. Med. Kinderheilk. 1924, 26:1), because cells with similar characteristics can be classified in the same category. The essence ota new concept is, according to Popper, that it must be susceptible to falsification. This has been attempted several times for the MPS by those who adhere to the RES. However, in biology no one can be certain of truth. Any theory must be based on experimental observations and/or theoretical consider ations and both should be presented in such a way that others can try to refute it, then or later. One may have a theoretical or a pragmatic preference for a theory which at a given time is regarded as possibly truc, but later it may be shown to be false. In other words, what we present in this volume is regarded as true at this moment, but others may consider it as not true and try to disprove it. Controversies often stimulate new research."

Recenzje

`This book comprises the proceedings of the fourth Leiden conference... Anybody with more than a passing interest in mononuclear phagocyte cells will want to have these proceedings available for consultation. ...this is a book that should be available in every pathology department where there is an interest in these cells.'
The Journal of Clinical Pathology (July 1986)
`These two large volumes contain the proceedings of the Third Conference on Mononuclear Phagocytes held in Leiden in September 1978. They contain a wealth of material which will be of value to those working with monocytes. These books contain papers on the structure, cytochemistry, origin and maturation, function and plasma membranes of the monocyte, their antimicrobial role, and role in the immune response. It should prove valuable as a source of reference and information in this important developing field.'
British Journal of Haematology, 47 (1981)
`...containing the meeting discussions as well as the reports, these proceedings surely embrace the 1978 'state of knowledge' with respect to the mononuclear phagocytic systems.'
Experimental Hematology, 9:1 (1981)
`The reticuloendothelial system died in Leiden in 1969 at the hands of Ralph van Furth and from iets ashes sprang the mononuclear phagocytes system. This massive two volume proceedings from the 3rd Leiden conference held in 1978 is a tribute to the vigour of this new phoenix and clearly documents its explosive growth. Nearly two thousand pages of erudite and informative papers and reviews describing the functional properties of macrophages are enclosed... The contents are entirely comprehensive covering a bewildering range of functional attributes of these remarkable cells. Until superseded by the proceedings of the fourth Leiden conference (and what a prospect that is!) these two volumes will undoubtedly become the definitive text for anyone interested in mononuclear phagocytes.'
Journal of Clinical Pathology (May 1981)
`For those interested in the occult mysteries and properties of one of the most fascinating but difficult cell series to trace in origin and function, this two-volume series on mononuclear phagocytes will prove exceptionally interesting. It is a relatively complete chronicle of the progress made over the past decade in elucidating the function and stem cell origin of renewing populations of mononuclear phagocytes and related cells. The two volumes will prove useful as references for both teaching and research.'
American Journal of Veterinary Research, 42 (1981)
`These two volumes constitute an important landmark in the study of 'inflammation'. ...well produced and should be of value, not only to cellular pathologists and scientists, but also to all of us concerned with human diseases.'
Journal of the European Society of Pathology (October 1980)

Spis treści

Surface properties of mononuclear phagocytes.- 1. Differentiation antigens of mouse macrophages and polymorphonuclear leukocytes.- 2. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80.- Discussion.- 3. The expression of antigen F4/80 and la on peritoneal macrophages in normal and BCG immunized mice.- Discussion.- 4. Human macrophage antigens.- Discussion.- 5. Immunocytochemical studies of human mononuclear phagocytes and dendritic cells.- Discussion.- 6. Quantitative analysis of monoclonal antibody binding to individual mononuclear phagocytes.- Discussion.- 7. The mannose receptor of macrophages: a current perspective.- Discussion.- 8. Soluble and membrane bound murine immunoglobulin Fc receptor.- Discussion.- 9. Internalization and fate of macrophage Fc receptors during receptor-mediated endocytosis.- Discussion.- 10. Macrophage membranes and clathrin.- Discussion.- 11. Heterogeneity of 5’-nucleotidase activity of wheat-germ agglutinin binding in mononuclear phagocytes.- Discussion.- 12. Inherited LFA-1, Mac-1 deficiency and its molecular biology.- Discussion.- 13. Bone marrow stromal cells — fibroblasts and macrophages.- Discussion.- Interactions of complement with membranes of mononuclear phagocytes.- 14. The role of complement in macrophage functions.- 15. Tissue and species specific regulation of complement biosynthesis in mononuclear phagocytes.- Discussion.- 16. Regulation of expression and cell surface motility of the C3b receptor on neutrophils and monocytes.- Discussion.- 17. Parameters of the stimulation of human monocytes by factor B of the complement system.- Discussion.- 18. Uptake and degradation of the Clq subcomponent of complement by adherent guinea pig peritoneal macrophages.- Discussion.- 19. Regulation of the function of receptors for C3b and C3bi on human mononuclear phagocytes by receptors for other ligands.- Discussion.- 20. Role of macrophage-complement receptors and macrophage complement uptake of zymosan.- Discussion.- In vivo kinetics and in vitro growth of mononuclear phagocytes.- 21. New perspectives on the kinetics of mononuclear phagocytes.- Discussion.- 22. The origins and turnover kinetics of limbocytes.- Discussion.- 23. Origin of osteoclasts from bone marrow mononuclear phagocytes.- Discussion.- 24. Mononuclear phagocyte progenitors and growth factors.- Discussion.- 25. Proliferation and differentiation of mononuclear phagocytes in vitro.- Discussion.- 26. Clonal analysis of bone marrow and macrophage cultures.- Discussion.- Secretion of products by mononuclear phagocytes.- 27. Control of apolipoprotein E secretion by macrophages.- Discussion.- 28. The secretion of lipoprotein lipase by mononuclear phagocytes.- Discussion.- 29. Autoregulatory effects of interleukin 1 on human monocytes.- Discussion.- 30. Macrophage elastase: regulatory concequences of the proteolysis of non-elastin tissue substrates.- Discussion.- 31. Determinants of generation and structural heterogeneity of fibroblast-activating principles of human mononuclear phagocytes.- Discussion.- 32. Signal-response coupling in the arachidonic acid cascade of macrophages.- Discussion.- 33. Influence of macrophage products on enzyme and prostglandin E2 release by chondrocytes.- Discussion.- Mobilization and chemotaxis of mononuclear phagocytes.- 34. Macrophage movements.- Discussion.- 35. Gelsolin: a calcium-modulated actin fragmenting protein in cytoplasm and plasma.- Discussion.- 36. Stimulus-response coupling of a chemoattractant receptor on mononuclear phagocytes.- 37. Mathematical analysis of the macrophage response to bacterial challenge in the lung.- Discussion.- Membrane electrophysiology of mononuclear phagocytes.- 38. Introduction to the membrane electrophysiology of mononuclear phagocytes.- 39. Membrane hyperpolarization and ionic channels in cultured human monocytes.- Discussion.- 40. Evidence for both a calcium-activated potassium conductance and an inward rectifying potassium conductance in macrophages.- Discussion.- 41. Potassium channels and conductance in cultured mouse peritoneal macrophages.- Discussion.- 42. Nature of transmembrane signal associated with binding to the macrophage IgG Fc receptor.- Discussion.- Intra- and extracellular cytotoxicity of mononuclear phagocytes.- 43. Regulation of macrophage oxidative metabolism and antiparasitic activity.- Discussion.- 44. Characterization of phagocyte NADPH oxidase.- Discussion.- 45. Role of the plasma membrane in the regulation of superoxide anion release by macrophages.- Discussion.- 46. Enhancement of the oxidative metabolic response of macrophages by proteolytic enzymes.- Discussion.- 47. Somatic hybridization of monocytes: a method to study the genetic heterogeneity of chronic gralunomatous disease and the molecular composition of the phagocyte oxidase system.- Discussion.- 48. Membrane stimulation and intracellular killing of micro-organisms by human monocytes.- Discussion.- 49. Influence of monocytes on the antibacterial activity of penicillin G on Staphylococcus aureus.- Discussion.- 50. Effects of nitrogenous bases on macrophage lysosomal movements and phagosome-lysosome fusion.- Discussion.- 51. Properties of resident and inflammatory macrophages in mouse liver.- Discussion.- 52. Tumor cell recognition and destruction by activated macrophages: effector and regulatory mechanisms.- Discussion.- Lymphokines and T-lymphocyte activation of mononuclear phagocytes.- 53. Dendritic cell-initiated T lymphocyte activation.- Discussion.- 54. Modulation of macrophage plasma membrane antigens and receptors by activation.- Discussion.- 55. Molecular characterization of macrophage activating factor for tumor cytotoxicity.- Discussion.- 56. The role of T cell clone- and hybridoma-derived lymphokines in macrophage activation.- Discussion.- 57. Role of T lymphocyte clones in cell-mediated immunity.- Discussion.- 58. Role of T lymphocytes during murine BCG infections.- Discussion.- 59. Role of T lymphocytes in granuloma formation.- Discussion.- 60. Refractory response of mouse lung macrophages to lipopolysaccharide.- Discussion.- 61. Induction of phenotypic alterations in macrophages by migration inhibitory factors.- Discussion.- Macrophages and intracellular pathogens.- 62. Interaction of schistosomes and macrophages.- Discussion.- 63. Interaction of macrophages and intra-erythrocytic malaria parasites.- Discussion.- 64. The endocytic system of Leishmania-infected macrophages.- Discussion.- 65. Interactions between human mononuclear phagocytes and Legionella pneumophila.- Discussion.- 66. Cell mediated immunity in lepromatous and tuberculoid leprosy.- Discussion.- Genetic control of the kinetics and functions of mononuclear phagocytes.- 67. Genetic control of macrophage response to infection.- Discussion.- 68. Genetic control of the humoral regulation of monocytopoiesis.- Discussion.- 69. Differences in intracellular killing of Salmonella typhimurium by macrophages of inbred mouse strains.- Discussion.- 70. The role of the macrophage in genetically controlled resistance and susceptibility to leishmaniasis.- Discussion.- Coagulation, vasculature, and mononuclear phagocytes.- 71. Cellular pathways and signals for the induction of biosynthesis of initiators of the coagulation protease cascade by cells of the monocyte lineage.- Discussion.- 72. Formation of blood coagulation factors by mononuclear phagocytes.- 73. The generalized Shwartzman reaction: effects of a glucocorticosteroid and endotoxin on thromboplastin synthesis by monocytes.- Discussion.- 74. Macrophage procoagulants and microvascular permeability: roles in the extravascular coagulation of cellular immunity.- Discussion.- 75. Monocyte receptors for fibronectin.- Discussion.- 76. Human monocyte interaction with platelets and endothelial cells: synthesis of arachidonic acid metabolites.- Discussion.- 77. Effects of mononuclear phagocytes and their secretory products on vascular endothelium.- Discussion.- 78. Interactions between leukocytes and endothelial cells in vitro.- Discussion.- 79. Regulation of angiogenesis by macrophages.- Discussion.- Macrophages in experimental pathology.- 80. Oxidant and protease effectors in acute inflammation.- Discussion.- 81. Glomerular injury: functional and phenotypic characteristics of resident and infiltrating macrophages.- Discussion.- 82. The role of the mononuclear phagocytes in primate and rabbit models of atherosclerosis.- Discussion.- 83. Macrophage lipoprotein metabolism in atherosclerosis.- Discussion.- 84. Role of monocytes in infective endocarditis.- Discussion.- Summation.- 85. Visions of the future?.