Molecular and Cellular Changes in the Cancer Cell: Volume 144

ISBN-13: 9780128093283 / Angielski / Twarda / 2016 / 616 str.

Kevin Pruitt

Opis

Molecular and Cellular Changes in the Cancer Cell, the latest volume in the Progress in Molecular Biology and Translational Science series, includes a comprehensive summary of the evidence accumulated thus far on the molecular and cellular regulation of the various adaptations taking place in response to exercise. This volume examines some of the latest advances, highlighting some of the most important molecular and cellular alterations and environmental influences that collectively cause a normal cell to become cancerous. Special emphasis is given to changes that take place at the molecular and cellular level.

• Comprehensive and up-to-date survey of current knowledge on the cancer cell
• Includes the latest advances and the most important molecular and cellular alterations and environmental influences collectively causing cells to become cancerous
• Written by leading experts in the field

Spis treści

1. Molecular and Cellular Changes During Cancer Progression Resulting from Genetic and Epigenetic Alterations K. Pruitt 2. Wnt/ß Catenin-mediated Signaling Commonly Altered in Colorectal Cancer J. Deitrick and W.M. Pruitt 3. Interplay between Inflammation and Epigenetic Changes in Cancer A.R. Maiuri and H.M. O'Hagan 4. Viral Carcinogenesis A.J. Smith and L.A. Smith 5. The Interaction between Human Papillomaviruses and the Stromal Microenvironment B. Woodby, M. Scott and J. Bodily 6. Molecular Pathogenesis of Pancreatic Cancer T.J. Grant, K. Hua and A. Singh 7. Current and Emerging Targeting Strategies for Treatment of Pancreatic Cancer A.T. Baines, P.M. Martin and C.J. Rorie 8. Molecular Changes Associated with Tumor Initiation and Progression of Soft Tissue Sarcomas; Targeting the Genome and Epigenome P.W. Halcrow, M. Dancer, M. Panteah, C. Walden and J.E. Ohm 9. Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification E. Karjalainen and G.A. Repasky 10. Myeloproliferative Neoplasms: Molecular Drivers and Therapeutics G.W. Reuther 11. Dysregulation of Aromatase in Breast, Endometrial, and Ovarian Cancers: An Overview of Therapeutic Strategies P.R. Manna, D. Molehin and A.U. Ahmed 12. Molecular Changes During Breast Cancer and Mechanisms of Endocrine Therapy Resistance S. Radhi 13. Molecular and Cellular Changes in Breast Cancer and New Roles of lncRNAs in Breast Cancer Initiation and Progression M. Kumar, R.S. DeVaux and J.I. Herschkowitz

O autorze

Kevin Pruitt received a BS degree in Chemical Engineering from University of Texas at Austin followed by post-baccalaureate research training in the biological sciences at the Los Alamos National Laboratory. He then moved on to the University of North Carolina at Chapel Hill, for doctoral studies in Pharmacology in 2001 followed by postdoctoral training at the Johns Hopkins School of Medicine. Dr. Pruitt has received numerous research awards during his career, serves as a member of National Cancer Institute study sections, and directs a vibrant research program where graduate students and postdoctoral trainees contribute to the discovery process in basic and translational cancer research. He joined the Physiology Department as an assistant professor at LSUHSC in Shreveport, Louisiana in 2006. He was then recruited to the Department of Immunology & Molecular Microbiology at TTUHSC in Lubbock, Texas in 2014 where his group continues to focus on identifying novel factors that contribute to colon and breast tumor progression.