Molecular Biology of the Arterial Wall

ISBN-13: 9783540178996 / Angielski / Miękka / 1987 / 170 str.

Gotthard Schettler

Opis

The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.

Spis treści

Workshop I Lipoproteins and Lipoprotein Receptors.- LDL Receptor Mutations in Patients with Familial Hypercholesterolemia.- Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B.- The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport.- Lipoproteins, Macrophages and Atherosclerosis.- Arterial Lipoprotein Metabolism: Site-Specific Differences Related to Susceptibility to Atherosclerotic Lesions.- Lipoprotein Disposition by the Liver: A Concerted Action of Various Cell Types.- The Macrophage and Endothelial Cell Scavenger Receptor.- Characterization of the Hepatic Scavenger Receptor.- Workshop II Growth Factors.- The Role of PDGF in Health and Disease.- Role of PDGF-like Growth Factors in Autocrine Stimulation of Cell Growth.- The PDGF Receptor as a Mediator of Mitogenesis.- Alpha-and Beta-Heparin Binding Growth Factors: Chemistry and Biology of Acidic and Basic Fibroblast Growth Factors.- Structure, Homologies and Activities of Acidic Fibroblast Growth Factor.- Endothelial Cell Growth Factor and its Receptor.- Workshop Ill Endocytosis and Exocytosis.- Intracellular Transport of Human Class I Antigens and an Adenoviral Glycoproteìn.- Molecular Mechanisms of Endocytic Sorting.- Characterisation of a Fusion Event from the Endocytic Pathway.- Membrane Boundaries Involved in the Selective Trafficking of Cell Surface Receptors.- The Molecular Basis of Human Cellular Iron Metabolism.- Workshop IV ONC Genes and Proliferative Disease.- Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis.- Transforming Activity of the fms Oncogene (CSF-1 Receptor).- Functional and Structural Analysis of the v-src and c-src Genes.- Ras Oncogenes and Cell Transformation.- Cis Regulatory Control of mos Oncogene Expression.- Analysis of the Function of the fos Oncogene Product.- Cooperative Interactions Involving Cellular and Viral Oncogenes in the Development of Malignant Tumors.- Workshop V White Blood Cells.- The Motor of Leukocytes and Platelets: 1986.- Heterogeneity of Murine and Human Fc? Receptors.- Complement Receptors.- Cachectìn: A Macrophage Protein that Induces a Catabolic State in Infected Animals.- The Role of Cytosolic Free Calcium, (Ca2+)i, and Phosphoinositides as Intracellular Signals.- The Macrophage-Blood Interface: Cell Localisation and Recruitment in Bone Marrow, Liver and Brain.- Normal and Neoplastic Early Lymphocyte Maturation.- Molecular Regulation of Complement Gene Expression.- Workshop VI Prostaglandins and Leukotrienes.- The Role of GTP-Binding Proteins in Coupling Prostaglandin and Leukotriene Receptors to Intracellular Second Messenger Systems.- Regulation of Vascular Tone by Prostaglandins and Endothelium-Derived Relaxing Factor.- Endogenous Cysteinyl Leukotrienes as Mediators in Endotoxin Shock and Tissue Trauma.- Source and Mechanism of Release of Arachidonic Acid in Blood Platelets.- Eicosanoids and the Pulmonary Circulation.- Regulation of the Production (Leukotriene A4 Hydrolase) and the Action (Leukotriene B4 Receptor Sites) of Leukotriene B4.- Enzymic Synthesis and Degradation of Prostaglandin D2.- Receptor-Dependent Regulation of Human Polymorphonuclear Leukocyte Responses to Leukotrienes.- Leukotriene C4-Binding Proteins.- Leukotriene C Metabolizing Enzymes.- Workshop VII Biology of Smooth Muscle and Endothelium.- The Fibrinolytic System of Cultured Bovine Aortic Endothelial Cells.- Tumor Necrosis Factor/Cachectin and the Modulation of Endothelial Cell Coagulant Properties.- Membrane Glycoproteins of Endothelial Cells and Platelets.- The Molecular Biology of Endothelial Cell von Willebrand Factor.- Induction and Regulation of Endothelial Gene Expression.- Endothelium-Vascular Smooth Muscle Interactions in Culture.- Endothelial Morphogenesis.- Closing Remarks.- Final Word.- List of Participants.- List of Sponsors.