Molecular Biology and Its Application to Medical Mycology

ISBN-13: 9783642846274 / Angielski / Miękka / 2012 / 257 str.

Bruno Maresca; George S. Kobayashi; Hideyo Yamaguchi

Opis

Presented here are recent achievements in molecular biology of non-pathogenic yeast and filamenous fungi as well as of human pathogens. Thebook is diveded into 4 sections: - Molecular Biology of Yeast; - Molecular Biology of Filamenous Fungi; - New Tools and Prospectives for Medical Mycology; - Fungal Morphogenesis. It focuses on aspects of medical mycology, namely isolation of specific genes and strategies for developing new targets for antifungal therapy.

Spis treści

Molecular Biology of Yeast.- Cell Cycle Regulation in Fission Yeast.- Yeast Genes Overcoming Growth Arrest Induced by 1,10-Phenanthroline.- Reverse Genetics in a Non-Conventional Yeast, Candida maltosa.- The Complement C3D-Binding Receptor (CR2) of Candida albicans: Cloning and Sequence Analysis of a Gene Fragment Homologous with a Human CR2 cDNA Clone.- Biology, Physiology, Biochemistry and Molecular Genetics of Trichosporon Yeasts.- Physiological Functions of Vacuoles in Yeast: Mechanism of Sequestration of Metabolites and Proteins into Vacuoles.- Characterization of a Candida albicans-Specific DNA Fragment.- Recent Advances in the Molecular Biology of Cryptococcus neoformans.- Molecular Biology of Kluyveromyces lactis.- Gene Regulatory Circuits in S. cerevisiae as a Tool for the Identification of Heterologous Eukaryotic Regulatory Elements.- Molecular Biology of Filamentous Fungi.- Molecular Breeding in Filamentous Fungi with Emphasis on Aspergilli.- TubB ?-Tubulin is Essential for Sexual Development in Aspergillus nidulans.- The Heat Shock Response of Neurospora crassa.- Blue Light Regulated Expression of Geranylgeranyl Pyrophosphate Synthetase (Albino-3) Gene in Neurospora crassa.- Expression of Genes for the Biosynthesis of Penicillin.- New Tools and Prospectives for Medical Mycology.- Imaging of the Yeast Killer Phenomenon.- cDNA Cloning of Candida albicans Aspartic Proteinase and Its Diagnostic Application.- Molecular Biotyping of Candida in Experimental and Clinical Studies.- Homoserine Dehydrogenase as a Selective Target Molecule for Antifungal Action.- Molecular Mechanisms of Antifungal Activity and Fungal Resistence: Focus on Inhibitors of Ergosterol Biosynthesis.- Molecular Studies on Azole Sensitivity in Fungi.- Antifungal Chemotherapy and Drug Strategies: Projected Clinical Needs.- Funding Medical Mycology: Strategies for Attracting the Private Sector.- Fungal Morphogenesis.- Chromosomal Organization of Histoplasma capsulation.- Chitin, Chitin Synthase and Chitin Synthase Conserved Region Homologues in Wangiella dermatitidis.- Heat Shock Response and Adaptation during Morphogenesis in Histoplasma capsulatum.