Molecular Aspects of Human Cytomegalovirus Diseases

ISBN-13: 9783642848520 / Angielski / Miękka / 2012 / 486 str.

Yechiel Becker; Gholamreza Darai; E. -S Huang

Opis

In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.

Spis treści

Section I Human Cytomegalovirus and Human Diseases.- 1 The Pathogenicity of Human Cytomegalovirus: An Overview.- 2 Pathology of Human Cytomegalovirus Infection.- 3 Cytomegalovirus Infection and Neonatal Hepatitis.- 4 Human Cytomegalovirus and Atherogenesis.- 5 Cytomegalovirus as a Sexually Transmitted Disease.- 6 Cytomegalovirus and Macrophage Interaction.- Section II Human Cytomegalovirus Infections and the Immuncompromised Host.- 7 Role of Cytomegalovirus Infection in Neurologic Abnormalities of Acquired Immunodeficiency Syndrome.- 8 Role of Cytomegalovirus Infection in Acquired Immunodeficiency Syndrome, with Emphasis on Neurological and Ophthalmological Complications.- 9 Cytomegalovirus and Blood Transfusion.- 10 Cytomegalovirus Infection After Solid Organ Transplantation.- 11 Cytomegalovirus Infection in Bone Marrow Transplantation.- 12 The Management of Cytomegalovirus Infection in Heart-Lung Transplant Recipients.- Section III Diagnosis, Treatment and Prevention of Human Cytomegalovirus and Human Diseases.- 13 Diagnosis of Human Cytomegalovirus Infection: Laboratory Approaches.- 14 The Control of Cytomegalovirus Infection: Chemotherapy.- 15 Vaccine Strategies for the Prevention of Cytomegalovirus Disease.- Section IV Molecular Aspects of Human Cytomegalovirus.- 16 Molecular Biology of Human Cytomegalovirus.- 17 Immediate-Early Genes of Human Cytomegalovirus: Organization and Function.- 18 Transcription Factors and Viral Regulatory Proteins as Potential Mediators of Human Cytomegalovirus Pathogenesis.- 19 Activation of Proto-oncogenes and Cell Activation Signals in the Initiation and Progression of Human Cytomegalovirus Infection.- 20 Potential Oncogenicity of Human Cytomegalovirus.- 21 Proteins of Human Cytomegalovirus that Elicit Humoral Immunity.- 22 Postscript: What Is the Role of Dendritic Cells in the Pathogenesis of Human Cytomegalovirus in Immunocompetent and Immunocompromised Hosts?.