Modern Trends in Human Leukemia VIII: New Results in Clinical and Biological Research Including Pediatric Oncology

ISBN-13: 9783540509677 / Angielski / Miękka / 1989 / 533 str.

Rolf Neth; Robert C. Gallo; Melvyn F. Greaves

Opis

You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.

Spis treści

Frederick Stohlmann Jr. Memorial Lecture.- Molecular Analysis of Rearrangements in Philadelphia (Ph1)Chromosome-Positive Leukemia.- Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy.- Clinical Aspects.- of Donald Pinkel.- Species-Specific Therapy of Acute Lymphoid Leukemia.- Current Issues and Future Directions in Marrow Transplantation.- The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods.- Clinicopathological Features and Prognostic Implications of Immunophenotypic Subgroups in Childhood ALL: Experience of the BFM-ALL Study 83.- Current Approaches to Therapy for Childhood Lymphoblastic Leukemia: St. Jude Studies XI (1984–1988) and XII (1988).- Results of Three Poly chemotherapy Programs in Non-Hodgin’s Lymphomas.- Results of Treatment in Children with B-Cell Lymphoma: Report on the Polish Leukemia/Lymphoma Study Group.- Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia.- Central Nervous System Involvement in Non-Hodgkin’s Lymphomas.- Targeted Plasma Drug Concentration: A New Therapeutic Approach to Relapsed Nonlymphoblastic Leukemia in Children.- Use of All-trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia.- Simultaneous Presentation of B- and T-Cell Malignant Lymphoma.- Phenotype Switch in Acute Leukemia Patients After Intensive Chemotherapy.- Expression of Cell Differentiation Antigens as a Prognostic Factor in Acute Leukemia.- Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol).- Constellations of Genetic Abnormalities Predict Clinical Outcome in Childhood Malignancies.- Leukemia Cytogenetics in Children: Results of the German Therapy Studies.- Cytostatic Influence of Thioproline on Peripheral Lymphocytes of Healthy Persons and Non-Hodgkin’s Lymphoma Patients.- Diversity of Molecular Phenotypes in Acute Leukemias.- Treatment of Chronic Myelogeneous Leukemia with Interferons: Hematologic, Cellular, and Genetic Investigations.- ? Interferon in Myelodysplasia.- Use of Investigational Drugs as Initial Therapy for Childhood Solid Tumors.- Xenografts of Pediatric Solid Tumors: Predictive Intermediate Models?.- Stromal-Hematopoietic Interrelationships: Maximow’s Ideas and Modern Models.- Bone Marrow Stromal Cells in Myelodysplasia Syndromes and Acute Nonlymphocytic Leukemia.- Growth and Development of Haemopoietic Cells: A Deterministic Process?.- Limited Proliferative Potential of Primitive Hematopoietic Stem Cells: Hematopoiesis by Clonal Succession.- The Effect of Human and Rat Fetal Bone Hematopoiesis In Vitro and In Vivo.- Aberrant Expression of the Multi-CSF Gene in Hematopoietic Precursor and Stem Cell Lines Initiates Leukemogenic Progression.- Infection of Multipotent IL-3-dependent Stem Cells With a Retroviral Vector Containing the IL-3 Gene Confers Density-dependent Growth Autonomy Without Blocking Differentiation.- Isolation of Revertants from a Factor-Independent Myeloid Cell Line.- Comparison of Factors which Induce Differentiation of the Murine Myeloid Leukaemic Cell Line M1.- Establishment of a Leukemic Cell Line MT-ALL With Multilineage Differentiation Potential.- Establishment of a Hybrid Cell System Between Malignant Burkitt’s Lymphoma Cells and Nonmalignant Lymphoblastoid Cells.- Effect of Natural and Synthetic Peptides on the Biological Function of Leukemic Cells.- Mechanisms of Glucocorticoid-Induced Growth Inhibition and Cell Lysis in Mouse Lymphoma Cells.- Characteristics of 27 Human T-Cell Leukemia Cell Lines With/Without T-Cell Receptors of T3-Ti?? or T3-Ti?? Complex.- Intervention in Potential Leukemic Cell Migration Pathway Affects Leukemogenesis.- Preleukemia in Experimental Leukemogenesis.- RAS Mutations in Preleukaemias.- Immunology.- Logical Structure of the Immunoregulatory Compartment.- Analysis of T Suppressor Cell-Mediated Tumor Escape Mechanisms Is Facilitated by the Selective In Vitro Activation of Tumor-specific Ts Cells.- Role of the Colony-Stimulating Factor-1 Receptor (c-fms) and Its Ligand in Oncogenesis.- Activation of CD4-Positive T Cells by Polysaccharide Fractions Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae).- Induction of Nonspecific Cell-Mediated Cytotoxicity: A Multisignal Event and its Cellular Regulation.- Signal Transduction Mechanisms in Human Natural Killer Cells Mediating Antitumor Immunity.- Tumor-Specific Antigens and Tumor-Specific Mutant Proteins in Mouse and Man.- Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma.- Disorders of the Expression of the Multichain IL-2 Receptor in HTLV-I-Associated Adult T-Cell Leukemia.- Monocyte Interleukin-1 Secretion Is Regulated by the Sequential Action of ?-Interferon and Interleukin-2 Involving Monocyte Surface Expression of Interleukin-2 Receptors.- The Expression of T-Cell Receptor-Associated Proteins in Normal and Leukemic Immature T-Cells.- Molecular Genetics.- Molecular Analysis of the Translocation Breakpoint in a Philadelphia-positive, bcr-negative ALL Patient.- Cloning of the Breakpoint Junction of the Translocation 14; 19 in Chronic Lymphocytic Leukemia.- Variant Breakpoint Positions on Chromosome 22 in Ph? Positive Chronic Myelogenous Leukemias.- Expression of Cellular Oncogenes in Primary Cells from Human Leukemias.- c-myc and c-myb Oncoproteins During Induced Maturation of Human Myeloid and Erythroid Leukaemic Lines.- Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus.- Cell Lineage Specifity of Chromatin Configuration and Gene Expression in Haemopoietic Progenitor Cells.- Chromosomal Translocations Involving the T-Cell Receptor ? Chain Locus and Two Loci on the Short Arm of Chromosome 11.- Genetic Markers for Oncogenes, Growth Factors, and Cystic Fibrosis.- Search for Genes Critical for the Early and/or Late Events in Carcinogenesis: Studies in Xiphophors (Pisces, Teleostei).- ras Gene Mutations and Clonal Analysis Using RFLPs of X-Chromosome Genes in Myelodysplastic Syndromes.- Close Localization of the Genes for GM-CSF and IL3 in Human Genome.- HIV-1, HTLV-I and the Interleukin-2 Receptor: Insights into Transcriptional Control.- HIV-1 Replication Requires an Intact Integrase Reading Frame.- Use of a HIV-1 Retroviral Vector System for Gene Transfer into Human Cells.- Multistage Mastocytoma Model Characterized by Autocrine IL-3 Production.- Purified Bovine NF-?B Recognizes Regulatory Sequences in Multiple Genes Expressed During Activation of T- and B-Lymphocytes.- Hematopoietic Growth Control by the T-Cell CD2 Determinant is Exerted at a Pretranslational Level.- Oncogene Cooperation and B-Lymphoid Tumorigenesis in Eµ-myc Transgenic Mice.- Even Transcriptionally Competent Proviruses Are Silent in Bovine Leukemia Virus Induced Tumor Cells.- Restriction Fragment Length Polymorphism of the c-Ha-ras-l Proto-Oncogene as a Marker of Genome Alterations and Susceptibility to the Development of Some Human Carcinomas.- Analysis of c-raf Oncogene Expression in Gastrointestinal Tumor Cells.- c-ets-2 and the Mitogenic Signal Pathway.- Induction of Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia Cells.- Expression and Chromosomal Assignment of a Novel Protein-Tyrosine Kinase Gene Related to the Insulin Receptor Family.- Genetic Characterization of a Human Endogenous Retroviral Element Located on Chromosome 18q21.- Human Endogenous Retrovirus-like Sequences.- Early Life and Evolution.- Fantasy of a “Virus” from the Inorganic World: Pathogenesis of Cerebral Amyloidoses by Polymer Nucleating Agents and/or “Viruses”.- Clay Minerals - Blueprints of Early Life.- Modern Coding Sequences Are in the Periodic-to-Chaotic Transition.- Translation to Human Temperaments of the Tyrosin-Kinase Active Site of the Human Insulin Receptor ?-Chain.