Modern Trends in Human Leukemia V: New Results in Clinical and Biological Research Including Pediatric Oncology

ISBN-13: 9783540118589 / Angielski / Miękka / 1983 / 518 str.

R. Neth; R. C. Gallo; M. F. Greaves

Opis

Levy, 10 Po: General Summary of the Meeting 507 Subject Index 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 515 1 Also special Lecture for the Wilsede Joint Meeting on Pediatric Oncolo- gy II 2 Were also presented in the Wilsede Joint Meeting on Pediatric Oncology II 3 Presented in the Wilsede Joint Meeting on Pediatric Oncology II xv Participants of the Meeting Anders, Fritz, Genetisches Institut der Universitaet, Heinrich-ButT-Ring 58-62,6300 Giessen, Federal Republic of Germany Bauer, Georg, Institut fuer Virologie im Zentrum fUr Hygiene, Hermann- Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Bell, Richard, Medical Oncology University Hospital, 75 East Newton Street, Boston, MA 02062, USA Bernhard, Silke, Dahlem-Konferenzen, Wallotstrasse 19, 1000 Berlin 33, Federal Republic of Germany Bister, Klaus, Max-Planck-Institut fUr Molekulare Genetik, Ihnestrasse 63-73, 1000 Berlin 33, Federal Republic of Germany Blattner, William A. , Family Studies Section, Environmental Epidemiology Branch, National Cancer Institute, Landow Building, Rm. 4C18, 7910 Woodmont Avenue, Bethesda, MD 20205, USA Boiron, Michel, Institut de Recherches sur les Leucemies et les Maladies du Sang, Universite Paris VII, Hopital Saint-Louis, 2 Place du Docteur-Four- nier, 75475 Paris Cedex 10, France Boniver, Jacques, Institut de Pathologie B 23, Laboratoire d'Anatomie, Pathologique, 4000 Liege, Belgium Bornkamm, Georg W. , Institut fuer Virologie im Zentrum fuer Hygiene, Hermann-Herder-Strasse 11,7800 Freiburg, Federal Republic of Germany Burgess, Antony W.

Spis treści

Frederick Stohlman Jr. Memorial Lecture.- Immunobiology of Lymphoid Malignancy.- Bone Marrow Transplantation in Leukemia1.- New Strategies in Diagnosis and Therapy.- Nucleotide Metabolism and Enzyme Inhibitors in Thymic Acute Lymphoblastic Leukaemia.- Selective Killing of Leukemia Cells by Inhibition of TdT.- Poly(A)-polymerase Levels in Leukemia.- Short-term Therapy for Acute Myelogenous Leukaemia in Younger Patients2.- Multicentre Pilot Study for Therapy of Acute Lymphoblastic and Acute Undifferentiated Leukaemia in Adults.- The Treatment of Acute Myelogenous Leukemia in Children and Adults: VAPA Update2.- Improved Results in Treatment of Acute Myelogenous Leukemia in Children – Report of the German Cooperative AML Study BFM-782.- Acute Myeloid Leukaemia in Childhood: Treatment in the United Kingdom2.- Interferon in Acute Myelogenous Leukaemia: A Preliminary Report.- Human Interferon-Beta in the Treatment of Non-Hodgkin Lymphoma.- Results of LSA2-L2 Therapy in Children with High-Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma.- Clinical and Epidemiological Observations on Acute Lymphoblastic Leukemia Subtypes at the Sheba Medical Center, Israel.- The Clinical Pharmacology of Cytosine Arabinoside.- Enhancement of the Cell-Mediated Lysis of Fresh Human Leukemia Cells by Cytostatic Drugs.- Secretion of Plasminogen Activators by Human Myeloid Leukemic Cells: Modulation and Therapeutic Correlations.- Bone Marrow Transplantation in West Germany in Patients with Leukemia3.- Cyclosporin A Following Matched and Mismatched Family Allogeneic Bone Marrow Transplants2.- Autologous Bone Marrow Transplantation in Acute Leukemia and Non-Hodgkin’s Lymphoma: A Phase I Study of 4-Hydroperoxycyclophosphamide (4HC) Incubation of Marrow prior to Cryopreservation2.- Serological Inhibition of Graft Versus Host Disease: Recent Results in 28 Patients with Leukemia.- Graft-Versus-Host Disease: Immunobiological Aspects2.- T-Cell Phenotypes in Mixed Leukocyte Reactions and After Bone Marrow Transplantation: Are Ia-Antigen on T-Cells a Marker for GvH Reactions?.- Monoclonal Antibody Therapy: “Model” Experiments with Toxin-Conjugated Antibodies in Mice and Rats.- In Vitro Cytodestruction of Leukemic Cells in Human Bone Marrow Using a Cocktail of Monoclonal Antibodies.- In Vitro Treatment with Monoclonal Antibody Prior to Autologous Bone Marrow Transplantation. in Acute Lymphoblastic Leukemia2.- Immunological Classification of Acute Lymphatic Leukemia.- Multimarker Analysis of Childhood Acute Lymphoblastic Leukemia (ALL): Heterogeneity of Cellular Phenotypes and Clinical Relevance of Immunological Defined ALL Subclasses.- Morphological and Cytochemical Features of Adult T-Cell Lymphoma-Leukaemia.- Activities and Specificities of N-Acetylneuraminyltransferases in Leukemic Cell.- WTl: A Monoclonal Antibody Reactive with T-ALL but not with Other Leukemias.- Dysfunctional Glucocorticoid Receptors in Acute Leukemia.- Glucocorticoid-Induced Lysis of Various Subsets of Acute Lymphoblastic Leukemia.- Epidemiology of HTLV-Associated Leukemia.- Current Prospects for Clinical Care of Acute Leukemia.- Mechanism of Malignant Transformation.- Viral Oncogenes and Cellular Prototypes.- The Transforming Gene of Avian Acute Leukemia Virus MC29.- Cellular onc Genes: Their Role as Progenitors of Viral onc Genes and Their Expression in Human Cells.- The Biology of an Oncogene, Based Upon Studies on Neoplasia in Xiphophorus.- The Transforming Gene of Avian Myeloblastosis Virus (AMY): Nucleotide Sequence Analysis and Identification of Its Translational Product.- DNA-Binding Ability of Transforming Proteins from Avian Erythroblastosis Virus and Mutant Avian Myelocytomatosis Virus, MC29, in Comparison with MC29 Wild Type.- Lack of Expression of Cellular Homologues of Retroviral onc Genes in Bovine Tumors.- Molecular Dissection of the Bovine Leukemia Virus Envelope Glycoprotein (BL V gp5l) by a Monoclonal Antibody Study.- Detection and Localization of a Phosphotyrosine-Containing onc Gene Product in Feline Tumor Cells.- The Use of cDNA Cloning Techniques to Isolate Genes Activated in Tumour Cells.- Cellular Transforming Genes in Cancer.- The Human onc Gene c-myc: Structure, Expression, and Amplification in the Human Promyelocytic Leukemia Cell Line HL-60.- Determination of Virulence Properties of Leukemia Viruses.- Generation of Recombinant Murine Leukemia Viruses De Novo: An Alternative Model for Leukemogenesis.- Expression of Retroviruses During Early Mouse Embryogenesis.- Natural History of M-MSV Tumors in Mice Carrying Endogenized Moloney Leukemia Virus.- Induction of Histiocytomas by Pristane Treatment of Mice Chronically Infected with Moloney Murine Leukemia Virus.- Purification of a Reverse Transcriptase-like Protein from the Plasma of a Patient with Chronic Myelogenous Leukemia and Production of Monoclonal Antibodies.- Detection of Group and Interspecies Reactivities in Mammalian C-Type Virus p30 Proteins and Corresponding Human Antigens.- Papovaviruses and Human Tumors.- Characterization of Proteins Induced by Herpesvirus saimiri: Comparative Immunoprecipitation and Analysis of Glycosylation.- Structural Organization and Expression of the Epstein-Barr Virus Genome.- Induction of Latent Epstein-Barr Virus Information by a Serum Factor.- Thymic Nurse Cells and Radiation Leukemia Virus Induced Thymic Lymphomas in C57BL Mice.- Construction and Characterization of Chromosomal DNA Libraries.- Human T-Cell Leukemia-Lymphoma Virus (HTLV): A Progress Report.- Early Events in the Suppression of Myeloid Leukemic Cells by Biological Regulators.- Myeloid Leukemic Cell Differentiation Induced by Human Postendotoxin Serum and Vitamin Analogues.- Effect of Colony-stimulating Factors on the Proteins Synthesized by Normal and Leukemic Myeloid Progenitor Cells.- Molecular Properties of a Factor Inducing Differentiation in Murine Myelomonocytic Leukemic Cells.- A Model Scheme for Human Hematopoietic Cell Differentiation as Determined by Multiple Markers of Leukemia-Lymphomas.- Studies on the In Vitro Microenvironment in Man.- Granulocyte-Macrophage Progenitor Cell Proliferation and Differentiation.- Proliferation and Maturation of Hemopoietic Cells from Patients with Preleukemia and Aplastic Anemia in Agar and Diffusion Chamber Cultures.- Persistent Deficiency of Myeloperoxidase and Lactoferrin in Granulopoietic Cells of Patients with Acute Leukemia.- Studies on Normal B-Cells and Common Acute Lymphoblastic Leukemia Blast Cells Using a Colony Assay.- Human Interleukin 2: Physiology, Biochemistry, and Pathophysiology in Lymphoblastic Leukemias and Immunodeficiency Syndromes.- Studies of Myelopoiesis Using Monoclonal Antibodies and Variant Lines from the Promyeloid Cell Line HL60.- Mechanisms for Induction of Differentiation in the Human Promyelocytic Cell Line HL-60.- Differentiation of a Human Myeloid Cell Line (HL-60) Toward Granulocyte-and Macrophage-like Cells: Comparison of Cell Surface Antigen Expression.- Transmission of Human T-Cell Leukemia Virus (HTLV) into Human Cord Blood T Cells.- K 562 Cell Line in Plasma Clot Diffusion Chambers: Changes in Cell Surface Phenotype in Relationship to Culture Conditions.- Antigen Expression on Normal and Leukaemic Erythroid Precursors.- The Early Stage of Friend Virus Erythroleukemias: Mechanisms Underlying BPA-“independent” In Vitro Growth of BFU-E.- Evidence for the Origin of Hodgkin and Sternberg-Reed Cells from a Newly Detected Small Cell Population.- Hodgkin’s Disease Cell Lines: Characteristics and Biological Activities.- Prelymphoma, Early Lymphoma, and Manifest Lymphoma in Immunosialadenitis (Sjögren’s Syndrome) - A Model of Lymphomagenesis.- Immunological Aspects in Malignancy.- B-Cell Malignancies: Origin and Extent of Clonal Involvement.- Transfection as an Approach to Understanding Membrane Glycoproteins.- Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8.- Human Histocompatibility Antigens.- Structure and Expression of Class I Genes of the Mouse Major Histocompatibility Complex.- Presence of HTLV in a Subset of T Cells from an Infected Patient: Some Immunochemical Properties of the Infected Cells.- Hybrids Between Human Cell Lines Belonging to Different Hematopoietic Pathways: Analysis of HLA and Myeloid Surface Antigens.- Natural Killer Cells and Their Targets: Impact of Differentiation on Target Cell Susceptibility.- Natural Cellular Defense Activities Against Tumors – Cytostasis and NK Activity.- Structure and Function of the Transferrin Receptor – A Possible Role in the Recognition of Natural Killer Cells.- NK and K Cells in Malignant Lymph Nodes.- Contrasuppression, Class I Antigens, and Cancer Immunity.- Inhibition of the Induction of Contra suppression by Antisera Against Tumor-Associated Surface Antigens on Methylcholanthrene-induced Sarcomas.- Dissection of a Unique Tumor-Specific Transplantation Antigen into Multiple Unique Independent Epitopes using Syngeneic T-Cell Lines.- Detection of Antigen-(AKR MuL V gp70)-Specific Circulating Immune Complexes (CIC) in Mice with Lymphomas.- Immunological Characterization of the Natural Antibodies to Human T-Cell Leukemia Virus in Human Sera.- General Summary.- General Summary of the Meeting.