Modern Trends in Human Leukemia IV: Latest Results in Clinical and Biological Research Including Pediatric Oncology

ISBN-13: 9783540106227 / Angielski / Miękka / 1981 / 560 str.

R. Neth; R. C. Gallo; T. Graf

Opis

Gut ist eine Lehrart, wo man vom Bekannten zum Unbekannten fortschreitet; schon ist sie, wenn sie sokratisch ist, d.i. wenn sie dieselben Wahrheiten aus dem Kopf und Herzen des Zuhorers herausfragt. Bei der ersten werden dem Verstand seine Uberzeugungen in Form abgefordert, bei der zweiten sie ihm abgelockt. Professor Friederich Schiller Jena, in a letter written on 23 February 1793 to his friend and supporter Korner, father of the poet Theodor Korner. Established clinicians and scientists as weil as students aga in tried the Wilsede experiment for three days and nights and learned from each other. In our fourth Wilsede meeting on "Modern Trends in Human Leukemia" we concentrated once again on questions re gar ding the practical application of research and its benefits to the patient. The main emphasis of leukemia research has changed since the first Wilsede meeting in 1973. Virology is no longer the sole interest. Advances in immunology and cell genetics and a better understanding of Dr. h. c. Alfred Toepfer speeking with participants of the meeting in Wilsede XXI Arrival and discussion of participants in front of the meeting pI ace "De Emmenhoff" XXII Personal and scientific discussion in Wilsede June 1980 Fotos: R. Vols XXIII the mechanisms regulating normal and pathological blood cell differen- tiation have had a considerable impact on the direction of leukemia research.

Spis treści

Frederick Stohlman Jr. Memorial Lecture.- The Relative Role of Viral Transformation and Specific Cytogenetic Changes in the Development of Murine and Human Lymphomas.- On the Biology and Immunology of Hodgkin’s Disease.- Clinical Aspects.- Chromosome Studies in Children and Adults with Leukemia1.- Myeloid Dysplasia: the Histopathology of Preleukemia.- Progress in Acute Myelogenous Leukemia.- VAPA10: A Treatment Program for Acute Myelocytic Leukemia.- Rational Approaches to the Treatment of Leukemia.- Treatment of Early Acute Nonlymphatic Leukemia with Low Dose Cytosine Arabinoside.- A Phase I Study of Human Lymphoblastoid Interferon in Patients with Hematological Malignancies.- Methods and Clinical Relevance of Terminal Deoxynucleotidyl Transferase Determination in Leukemic Cells2.- Quantitation of Chemotherapy-Induced Cytoreduction in Acute Leukemia2.- Intensive Therapy and Prognostic Factors in Acute Lymphoblastic Leukemia of Childhood: CCG 141. A Report from Childrens Cancer Study Group2.- Treatment Strategy for Different Risk Groups in Childhood Acute Lymphoblastic Leukemia: A Report From the BFM Study Group2.- Recurrent Childhood Lymphocytic Leukemia: Outcome of Marrow Relapses After Cessation of Therapy2.- The Treatment of Primary Childhood Acute Lymphocytic Leukemia with Intermediate Dose Methotrexate2.- Present Problems in Management of Childhood Lymphoblastic Leukaemia: Experience from the Hospital for Sick Children, London2.- Different Therapy Protocols for High Risk and Standard Risk ALL in Childhood.- T-Cell Acute Lymphoblastic Leukemia in Children2.- The Concept of GvHD-Suppression by In Vitro Treatment with Antisera2.- Bone Marrow Transplantation for the Treatment of Leukemia.- Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia in First Remission.- Use of Erythrocyte Ghosts for Therapy.- A Possible Biochemical Basis for the Use of Hyperthermia in the Treatment of Cancer and Virus Infection.- Cytogenetic Aspects of Lymphomas.- The Implications of Nonrandom Chromosome Changes for Malignant Transformation.- Regional Gene Mapping of Human Chromosomes Purified by Flow Sorting.- The Different Origin of Primary and Secondary Chromosome Aberrations in Cancer.- Insertion of New Genes into Bone Marrow Cells of Mice.- Organization of the Methotrexate Resistant Mouse L5178YR Dihydrofolate Reductase Gene and Transformation of HumanHCT-8 Cells by This Gene.- Structure of the Lysozyme Gene and Expression in the Oviduct and Macrophages.- Some Recent Trends in Studies of Human Lymphoid Cells: B-Cells, Epstein-Barr Virus, and Transformation.- Epstein-Barr Virus: Its Site of Persistence and Its Role in the Development of Carcinomas.- Episomal and Nonepisomal Herpesvirus DNA in Lymphoid Tumor Cell Lines.- B-Lymphotropic Papovavirus (LPV) — Infections of Man?.- Immunopathology of the X-Linked Lymphoproliferative Syndrome.- Surface Characteristics of the U-937 Human Histiocytic Lymphoma Cell Line: Specific Changes During Inducible Morphologic and Functional Differentiation In Vitro.- Enzyme Polymorphism as a Biochemical Cell Marker: Application to the Cellular Origin and Homogeneity of Human Macrophages and to the Classification of Malignant Lymphomas.- Human Leukemic Lymphocytes — Biochemical Parameters of the Altered Differentiation Status.- Lymphoproliferation and Heterotransplantation in Nude Mice: Tumor Cells in Hodgkin’s Disease.- Cell Biological and Immunological Aspects.- Genetic and Oncogenic Influences on Myelopoiesis.- Acidic Isoferritins as Feedback Regulators in Normal and Leukemic Myelopoiesis.- Assessment of Human Pluripotent Hemopoietic Progenitors and Leukemic Blast-Forming Cells in Culture.- Proliferation and Maturation of Hemopoietic Cells in Adult Patients with Different Forms of Acute Leukemia and Chronic Myeloid Leukemia in Agar and Liquid Cultures.- Cytological and Cytochemical Analysis of Plasma Clot Cultures and Peripheral Granulocytes Related to Long Term Survival in Childhood ALL and Cancer Patients Under Cytostatica Therapy.- Maturation of Blast Cells in Acute Transformation of Chronic Myeloproliferative Syndrome.- Patterns of Cell Surface Differentiation of cALL Positive Leukemic Blast Cells in Diffusion Chamber Culture.- Maturation of Human Peripheral Blood Leukemic Cells in Short-Term Culture.- Regulator-Dependent Hemopoiesis and Its Possible Relevance to Leukemogenesis.- Long-Term Culture of Normal and Leukemic Human Bone Marrow.- Corticosteroid Dependence of Continuous Hemopoiesis In Vitro with Murine or Human Bone Marrow.- Cloning Cells of the Immune System.- Comparative Antigenic Phenotypes of Normal and Leukemic Hemopoietic Precursor Cells Analysed with a “Library” of Monoclonal Antibodies2.- Surface Antigens of Pluripotent and Committed Haemopoietic Stem Cells.- Human Leucocyte Antigens.- Immunologic Subsets in Human B-Cell Lymphomas in Relation to Normal B-Cell Development.- Clones of Murine Functional T Cells.- Marker Profiles of Leukemia-Lymphoma Cell Lines2.- Biochemical Characterization of an Antigen Associated with Acute Lymphoblastic Leukemia and Lymphocyte Precursors2.- Serologic Subtyping of cALL2.- Acute Myeloblastic Leukemia-Associated Antigens: Detection and Clinical Importance2.- Glycophorin A as an Erythroid Marker in Normal and Malignant Hematopoiesis2.- The Network Concept and Leukemia.- Interpretation and In Vivo Relevance of Lymphocytotoxicity Assays.- Acute Leukemia and Nonspecific Killer Cells.- The Use of Bacteria as Markers of Leukemic Lymphocytes and for the Isolation of Natural Killer Cells.- Receptor Mediated Murine Leukemogenesis: Monoclonal Antibody Induced Lymphoma Cell Growth Arrest.- Effect of Bromodeoxyuridine on Endogenous Retrovirus Production in Differentiating Murine Lymphocytes.- Modulation of Growth of Malignant Cells by Anti-Idiotypic Immunity.- Thymic Nurse Cells: Intraepithelial Thymocyte Sojourn and Its Possible Relevance for the Pathogenesis of AKR Lymphomas.- Generation of Stable Antigen Loss Variants from Cloned Tumor Lines — An Example of Immunoadaptation During Metastasis.- Virological and Molecularbiological Aspects.- Transforming Genes of Retroviruses: Definition, Specificity, and Relation to Cellular DNA.- A Cellular Protein Phosphorylated by the Avian Sarcoma Virus Transforming Gene Product.- Correlated Loss of the Transformed Phenotype and pp60src-Associated Protein Kinase Activity.- The Transformation-Specific Protein pp60src from an Avian Sarcoma Virus.- Proteolytic Processing of Avian and Simian Sarcoma and Leukemia Viral Proteins.- Control of Protein Synthesis. Phosphorylation and Dephosphorylation of Eukaryotic Peptide Initiation Factor 2.- Characterization of the Hematopoietic Target Cells of Defective Avian Leukemia Viruses by Velocity Sedimentation and Density Gradient Centrifugation Analyses.- PRCII, a Representative of a New Class of Avian Sarcoma Viruses.- Identification of the Avian Myeloblastosis Virus Genome.- Genetics of Leukemogenesis by Avian Leukosis Viruses.- Avian Lymphoid Leukosis is Correlated with the Appearance of Discrete New RNAs Containing Viral and Cellular Genetic Information.- The Molecular Basis of Avian Retrovirus-Induced Leukemogenesis.- Studies of the Association of Leukemogenic and Oncogenic Properties in Avian Leukemia Viruses.- Genetic Approaches Toward Elucidating the Mechanisms of Type-C Virus-Induced Leukemia.- The Long Terminal Repeat of Moloney Sarcoma Provirus Enhances Transformation.- Ontogeny of Abelson Murine Leukemia Virus Target Cells.- Structural and Functional Studies of the Friend Spleen Focus-Forming Virus: Structural Relationship of SFFV to Dualtropic Viruses and Molecular Cloning of a Biologically Active Subgenomic Fragment of SFFV DNA.- Enhancing Effect of Murine Leukemia Virus on Fibroblast Transformation by Normal BALB/C Mouse DNA Fragments.- Role of Viruses in the Etiology of Naturally Occuring Feline Leukemia.- Relationship of the Feline Oncornavirus Associated Cell Membrane Antigen to a Feline Sarcoma Virus Encoded Polyprotein.- Feline Leukemia Virus Nonproducer Lymphosarcomas of Cats as a Model for the Etiology of Human Leukemias.- Genomic Integration of Bovine Leukemia Provirus and Lack of Viral RNA Expression in the Target Cells of Cattle with Different Responses to BLV Infection.- Natural Antibodies to BLV gp51 Are Reactive Against the Carbohydrate Moiety of the Glycoprotein.- Regulation of Human T-Cell Proliferation: T-Cell Growth Factor and Isolation of a New Class of Type-C Retroviruses from Human T-Cells.- Characterization by Nucleic Acid Hybridization of HTLV, a Novel Retrovirus from Human Neoplastic T-Lymphocytes.- Different Frequency Classes of Sequences in Heterogeneous Nuclear RNA of Normal Promyelocytes and Lymphoblasts and of Leukemic Blast Cells of Circulating Blood and of the HL60 Line.- Characterization of Antigens in SSV Nonproducer Cells.- Viral Gene Expression in Cells Transformed by Simian Sarcoma Virus, an Infectious Primate Type C Retrovirus.- Cell Fusion as a Tool for the Detection of Viral Footprints in Childhood Leukemia.- ELISA for the Detection of Antigens Cross-Reacting with Primate C-Type Viral Proteins (p30, gp70) in Human Leukemic Sera.- Radiation-Induced Murine Leukemias and Endogenous Retroviruses: The Time Course of Viral Expression.- Retrovirus Particle Production in Three of Four Human Teratocarcinoma Cell Lines..- General Summary.- General Summary.