Modern Trends in Human Leukemia III: Newest Results in Clinical and Biological Research

ISBN-13: 9783540089995 / Angielski / Miękka / 1979 / 600 str.

R. Neth; R. C. Gallo; P. -H Hofschneider

Opis

"Es ist ja ganz eineriei, wer es gejunden hat, die Hauptsache ist, daB es gejunden worden ist." This was said by Hermann Wilbrand, director of the department of opthalmology at the university hospital Hamburg-Eppendorf (1919-1923), when others claimed priority for the long searched for cortical visuell center, which he had discovered. Five years ago we tried in Wilsede an unusual experiment, bringing together for three long days and nights scientists and medical doctors to learn like students about each others work. The hope was that the participants in the workshop would discuss the whole problem of human leukemia, and coopera tive programmes among the different specialized research groups and medical centers would be stimulated. Now five years later we feel that the experiment was a success. Coope rative research programmes around the world were started and most of us understand more and more the Frederic Stohl man question about the pratical application of our research and its benefit for the patient. The chairman have done a tremendous job organizing an up to date scientific programme for the third Wilsede meet ing. I would like to thank all of them for a programme which includes all the important results and future aspects of human leukemia."

Spis treści

Frederick Stohlman Jr. Memorial Lecture.- Memorial Tribute to Dr. Frederick Stohlman, Jr..- Cellular and Virological Studies Directed to the Pathogenesis of the Human Myelogenous Leukemias.- Treatment of Childhood Acute Lymphocytic Leukemia.- Clinical Aspects.- Epidemiology of Leukemia.- Chromosome Abnormalities in Leukemia.- Use of Glucose-6-Phosphate Dehydrogenase Markers to Study Human Myeloproliferative Disorders.- Histopathology of Bone Marrow in Human Chronic Leukemias.- Bone Marrow Transplantation in Acute Leukemia: Current Status and Future Directions.- Impact of Specific Immunotherapy in Acute Myelocytic Leukemia.- Treatment of Adult Acute Myeloblastic Leukemia.- Prediction of Therapeutic Response in Acute Myelocytic Leukemia.- Prognostic Factors in Adult Acute Lymphoblastic Leukemia.- Ultrastructure and Cell Marker Studies in Lymphoproliferative Disorders.- Intermediate Dose Methotrexate (IDM) in Childhood Acute Lymphocytic Leukemia (ALL).- Marrow Terminal Deoxynucleotidyl Transferase Activity in Adult Acute Leukemia.- Clinical Significance of TdT, Cell Surface Markers and CFU-C in 297 Patients with Hematopoietic Neoplasias.- Biochemical Determinants for Antileukemia Drug Treatment.- Biological and Clinical Effects of a Partially Thiolated Polycytidylic Acid (MPC): A Potent Inhibitor of DNA Synthesis in RNA Tumor Viruses.- Summary of Clinical Poster Sessions.- Progress in Acute Leukemia 1975–1978.- Cell Biology.- Regulatory Interactions in Normal and Leukemic Myelopoieses.- Leukemic Inhibition of Normal Hematopoiesis.- Clonal Diseases of the Myeloid Stem Cell Systems.- Intramedullary Influences on in Vitro Granulopoiesis in Human Acute Myeloid Leukemia.- Analysis of Myeloproliferative Disorders Using Cell Markers in Culture.- Morphologic Characteristics of Human Blood Cells in Semi-Solid Marrow Cultures.- Differentiation Ability of Peripheral Blood Cells from Patients with Acute Leukemia or Blast Crisis in Chronic Myelocytic Leukemia.- Modification of the Proliferative and Differentiation Capacity of Stem Cells Following Treatment with Chemical and Viral Leukemogens.- Characterization of Myelomonocytic Leukemia Cells Induced by in Vitro Infection of Bone Marrow with FLV.- Epstein Barr Virus (EBV) and Complement (C3) Interactions With Human Lymphoid Cells.- Molecular Biology.- Anatomy of the RNA and Gene Products of MC29 and MH2, two Defective Avian Tumor Viruses Causing Acute Leukemia and Carcinoma: Evidence for a new Class of Transforming Genes.- Studies on the Structure and Function of the Avian Sarcoma Virus Transforming Gene Product.- The in Vitro Translation of Rous Sarcoma Virus RNA and Function of the Viral Protein During the Viral Replication.- Regulation of Translation of Eukaryotic Virus mRNAs.- Control of Eukaryotic Protein Synthesis by Phosphorylation.- Cell-free Protein Synthesis and Interferon Action: Protein Kinase(s) and an Oligonucleotide Effector, pppA2?p5?A2?p5?A.- Alterations in Translational Control Mechanisms in Friend Erythroleukemic Cells During DMSO Induced Differentiation.- Inhibition of Polypeptide Chain Initiation by Inducers of Erythroid Differentiation in Friend Erythroleukemic Cells.- Possible Role of the Friend Virus Life Cycle in Differentiating Friend Leukemia Cells Treated with Interferon.- Genetic Analysis of Human Cell Surface Structures.- Effect of Vitamin A on Plasminogen Activator Synthesis by Chick Embryo Fibroblasts.- The Molecular Biology of Differentiation and Transformation: An Emerging Field Theory?.- Immunology.- Leukemic Cell Phenotypes in Man: Relationship to “Target” Cells for Leukemogenesis and Differentiation Linked Gene Expression.- Characterization of Antigens on Acute Lymphoblastic Leukemias.- Common All Associated Antigen from Cell Surface and Serum: Molecular Properties and Clinical Relevance.- Monoclonal Antibodies to Human Cell Surface Antigens.- Elicitation of Anti-Leukemia Cytotoxic Responses.- Histocompatibility Antigens and T Cell Responses to Leukemia Antigens.- T Cell Function in Myelogenous Leukemia.- Recognition of Simian Sarcoma Virus Antigen by Human Sera.- Studies of Human Serological Reactivity with Type C Virus and Viral Poteins.- A Search for Type-C Virus Expression in Man.- Tumor Cell Mediated Degradation in Vitro of Antitumor Antibodies.- Evidence Supporting a Physiological Role for Endogenous C-Type Virus in the Immune System.- Immunological Aspects.- Virology.- to Oncogenesis by RNA Tumor Viruses.- Mechanism of Leukemogenesis and of Target Cell Specificity by Defective Avian Leukemia Viruses: A Hypothesis.- Infectious Leukemias in Domestic Animals.- Biochemical and Epidemiological Studies on Bovine Leukemia Virus (BLV).- Leukemia Specific Antigens: FOCMA and Immune Surveillance.- A Single Genetic Locus Determines the Efficacy of Serum Therapy Against Murine Adenocarcinoma 755a.- The Search for Infectious Viral DNA in Human Leukemic Cells.- Infection of Mouse Bone Marrow Cells with Abelson Murine Leukemia Virus and Establishment of Producer Cell Lines.- Cocultivation as a Tool for the Detection of Oncoviruses in Childhood Leukemia.- Evidence for the Presence of an Oncornaviral Reverse Transcriptase in an Orbital Tumor Associated to Acute Myelomonocytic Leukemia in Children: Biochemical and Immunological Characterization of the Enzyme.- Inactivation and Lysis of Oncornaviruses by Human and Primate Complement.- Exchange of Genetic Material.- The Role of Gene Rearrangement in Evolution.- Bacterial Transposons.- The Virus-Cell Gene Balance. Model of Cancerogenesis.- Comparative Analysis of RNA Tumor Virus Genomes.- Detection of Integrated Type-C Viral DNA Fragments in Two Primates (Human and Gibbon) by the Restriction Enzyme Blotting Technique.- Genetic Transmission of Moloney Leukemia Virus: Mapping of the Chromosomal Integration Site.- Integration Sites for Moloney Murine Leukemia Virus DNA in Infected Mouse Cells.- Release of Particle Associated RNA Dependent DNA Polymerases by Primary Chicken and Quail Embryo Cells.- Pluripotent Teratocarcinoma — Simian Virus 40 Transformed Mouse Fibroblasts Somatic Cell Hybrids.- Summary of the Meeting.- Summary of Meeting on Modern Trends in Human Leukemia III.