Modern Trends in Human Leukemia II: Biological, Immunological, Therapeutical and Virological Aspects

ISBN-13: 9783540797852 / Angielski / Miękka / 1983 / 577 str.

R. Neth; R. C. Gallo; K. Mannweiler

Opis

mene Stil in jeglicher Kunst, daft er die spezijischen Schranken derselben zu entfernen weip, ohne doch ihre spezijischen Vorzuge mit aufzuhe- ben, und durch eine weise Benut- zung ihrer Eigentumlichkeit ihr einen mehr allgemeinen Charakter erteilt. Friedrich Schiller - Ober die as the- tische Erziehung des Menschen. In den Horen, 22. Brief (1795) We are glad that you have all come to this small village and I hope that you will feel at home here for the next few days. The special atmosphere of the surround- ings will probably have a good influence on our discussions, and you will perhaps remember this when you are back home again. It takes hard work to save this little piece of nature for man in our highly industrialized world, and we should all be grateful to the Verein Naturschutzpark e. V. (founded in 1909), Alfred Toepfer and his associates for their efforts. We intend to discuss modern trends in human leukemia in this workshop, but we should also take the opportunity to reflect on the trends of the past, which might still be modern.

Spis treści

Cell Biology of Leukemia.- Notions about the hemopoietic stem cell.- Productivity in normal and leukemic granulopoiesis.- Cytology and cytochemistry of colony cells in soft agar gel culture from normal and leukemic bone marrow.- Cellular subclasses in human leukemic hemopoiesis.- Characterisation and pathological growth of human bone marrow cells by means of a new stem cell assay.- The phenotypic abnormality in leukemia: a defective cell-factor interaction?.- In vitro colöny growth of acute myelogenous leukemia.- Clinical utility of bone marrow culture.- Proliferative behavior of hemopoietic cells in preleukemia and overt leukemia observed in one patient.- Leukemic anaplasias reflecting physiologic cytogenesis of myeloid system.- Membrane remodeling during phagocytosis in chronic myelogenous leukemia cells.- Erythroid cell differentiation.- Molecular mechanisms in erythroid differentiation.- Analysis by computer controlled cell sorter of Friend virus-transformed cells in different stages of differentiation.- Hormone independent in vitro erythroid colony formation by mouse bone marrow cells.- In vitro and preliminary in vivo studies of compounds which induce the differentiation of Friend leukemia cells.- Target cells for leukemic transformation by chicken C-type viruses.- Fusion experiments with human tumour cells.- Effect of cytochalasin B on malignant cells.- Growth regulation and suppression of metastasis in the congenitally athymic nude mouse.- Immunology of Leukemia.- Cell-mediated immunity to leukemia associated antigens in experimental models and in man.- Surface features of cells in human lymphoproliferative disorders. An immunoelectron microscopy study.- Immunological characterization of blast cells in patients with acute lymphoblastic leukemias. Evaluation of its clinical significance.- Immunological membrane markers of Hodgkin’s cells.- Human leukemia-lymphoma associated antigen detected by heteroantisera.- Analysis of human leukaemic cells using cell surface binding probes and the fluorescence activated cell sorter.- Use of immunological reagents prepared in animals to characterise the surface of leukaemic cells.- Therapy of Leukemia.- Trends in the treatment of childhood leukemia.- The therapy of acute leukemia in the adult. A progress report.- Aids in the management of leukemia (cell removal by continuos flow leukapheresis and impulse cytophotometry).- The place of immunological methods of treatment in the management of acute leukaemia.- Perspectives and prospectives in the management of acute leukemia.- Oncogenic Viruses in Leukemia.- Restricted addition of proviral DNA in target tissues of chickens infected with avian myeloblastosis virus.- Sequences and functions of Rous sarcoma virus RNA.- Infection of developing mouse embryos with murine leukemia virus: tissue specificity and genetic transmission of the virus.- Type C virogenes: modes of transmission and evolutionary aspects.- Bovine leukemia virus: an exogenous RNA oncogenic virus?.- Molecular evidence for the association of RNA tumor viruses with human mesenchymal malignancies.- RNA tumor viruses and leukemia: evaluation of present results supporting their presence in human leukemias.- Murine and simian C-type viruses: sequences detected in the RNA of human leukemic cells by the c-DNA probes.- Prevention of herpes-associated malignancies in primates: problems and prospects.- New properties of mammalian cells transformed by herpes simplex and cytomegalo-viruses.- Failure to immortalize human ‘null’ cells by Epstein Barr virus (EBV) ‘in vitro’.- The role of viruses in human leukemia: a summary.- RNA Synthesis and Translation in Leukemic Cells.- IS-element in bacteria.- Circadian variation of «-amanitine sensitive RNA-synthesis in normal human lymphocytes.- Terminal deoxynucleotidyl transferase as a biological marker for human leukemia.- Terminal deoxynucleotidyl transferase in normal and neoplastic hematopoietic cells.- A new, not virus related reverse transcriptase in the chicken system.- Translation level control in normal and leukemic cells.- Control of peptide chain initiation in uninfected and virus infected cells by membrane mediated events.- List of Participants.