Micro- And Nanotechnology in Vaccine Development

ISBN-13: 9780323399814 / Angielski / Twarda / 2016 / 460 str.

Mariusz Skwarczynski; Istvan Toth

Opis

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.

• Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development
• Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development
• Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Recenzje

"Overall, all the chapters uniquely illustrate various advantageous opportunities that micro- and nanotechnologies may contribute to the development of more precise and effective, as well as safe and economical vaccines without omitting risks and challenges that are still given today. Therefore, this book is a suitable reference for further research on vaccine development in a dawning era of nanotechnology in vaccination and immunotherapy." --ChemMedChem

Spis treści

Overview of immune system.
Innate immunity and special role of antigen presenting cells.
Immunity and size.
Introduction to the vaccines.
Current challenges in vaccine development.
Growing role of nanotechnology
Nanotechnology in medical research
Nanoparticle based peptide vaccines
Liposome as nano- and microvaccines
Lipid in peptide vaccine (excluding liposomes)
Nanoadjuvants for peptide based vaccines
Nanopatches for vaccine delivery
Oral vaccine delivery
Nano- and microtechnology in skin delivery of vaccines
Nasal vaccine delivery
Nanoparticles for cancer targeting vaccines by
polymer based nanovaccines
Lipidic microparticles for vaccine delivery
Polymeric microparticles for vaccine delivery