Methods in Inhalation Toxicology

ISBN-13: 9780849333439 / Angielski / Miękka / 1996 / 176 str.

Phalen F. Phalen; Robert F. Phalen

Opis

Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research.
The book covers techniques needed to:

provide suitable clean air for experiments

correctly generate the particles and gases being studied

select the proper exposure system

monitor the exposure

prepare tissues for study

ensure that animals do not have confounding lung disease
The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.

Recenzje

[The authors] have written a clearly delineated introduction, appropriate for graduate students beginning a career in laboratory-based inhalation toxicology, but equally useful for seasoned investigators whose work leads them into one or more aspects of the field."
-Journal of Aerosol Medicine

Spis treści

Introduction, R.F. PhalenAnimal Quality and Protocol Approval, W.J. Mautz and M.T. KleinmanCleaning the Air, R.F. PhalenExposure Atmosphere Generation and Characterization, M.T. Kleinman and R.F. PhalenInhalation Exposure Methods, R.F. PhalenAnimal Monitoring, W.J. MautzTissue Acquisition and Processing, R. RasmussenSpecialized Sampling Techniques, D.K. BhallaIndex

O autorze

Phalen, Robert F.