Metallopharmaceuticals II: Diagnosis and Therapy

ISBN-13: 9783540653080 / Angielski / Twarda / 1999 / 216 str.

M. J. Clarke; P. J. Sadler; Michael J. Clarke

Opis

Biological inorganic chemistry is an interface of two seemingly disparate areas. The rapidly developing insights into the role of metals in biological systems presented in this text have far-reaching implications, not only for biological science but also for related disciplines.

Spis treści

Tweedle, M.F., Kumar, K.: Magnetic Resonance Imaging(MRI) Contrasting Agents,- Packard, A.: Radiopharmaceuticals,- Rhule, J.T., Hill, C.L., Zheng, Z.: Polyoxometallates and Fullerenes as Anti-HIV Agents,- Orvig, C., Thompson, K.H.: Vanadium Insulin Mimetics,- Sunn, H., Sadler, P.J.: Bismuth Antiulcer Complexes,- Shaw, C.F.: Gold Anti-Arthritic Agents.

Blurb

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magentic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The succcessful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.