Metal-Organic Framework Nanoparticles as Drug Delivery System

ISBN-13: 9786205510049 / Angielski / Miękka / 52 str.

Mohamed G. El-Desouky

Opis

Metal-organic framework (MOF) hybrid materials could be one of the answers in this investigation. We describe a simple and effective encapsulation of doxorubicin (DOX), an anticancer drug, inside Zr-MOF, which drug delivery organizations have little studied. We investigated the measured release of the drug from Zr-MOF in response to external incentives such as pH changes and interaction with biomimetic schemes. Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF) can be manufactured in one pot by adding the anticancer medication DOX to the reaction combination. They demonstrated pH-responsive medication release and cancer cell-killing capability. MOFs can be designed as multifunctional distribution vehicles for various loads, including medicinal and imaging agents, using our simple one-pot approach. FT-IR, X-ray diffraction, scanning electron microscopy, and N2 sorption isotherm was used to analyze MOF and the developed drug delivery (DOX@Zr-MOF) scheme. It investigated the effects of MOF and a bespoke drug delivery system on the feasibility of patient breast and liver tumor cell lines.

O autorze

Dr. Mohamed G. El-Desouky M.SC. in inorganic chemistry; Thermal and Spectroscopic Studies of Some Prepared Metal Complexes with Expected Antimicrobial and Anticancer Activities, Ph.D. in Analytical chemistry; Removal of Some Pollutants Using Some Adsorption Materials. and work at Egyptian Propylene and Polypropylene Company.