Membrane Organization and Dynamics

ISBN-13: 9783319666006 / Angielski / Twarda / 2017 / 387 str.

Amitabha Chattopadhyay

Opis

This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The articles in this volume cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide a comprehensive understanding of the underlying membrane dynamics and function. This will help to develop robust models for understanding membrane function in healthy and diseased states from a dynamic perspective.
Biological membranes are complex two-dimensional, non-covalent assemblies of a diverse variety of lipids and proteins. They impart an identity to the cell and its organelles and represent an ideal milieu for the proper function of a large set of membrane proteins. Membrane proteins occupy a central role in cellular physiology. They mediate a wide range of essential cellular processes such as signaling across the membrane, cell-cell recognition, and membrane transport. Almost 50% of all proteins encoded by a eukaryotic genome are membrane proteins. As a result, a majority of biological processes take place on the cell membrane. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu.

Spis treści

Table of Contents

1 Biomembrane Organization and Dynamics: What is So Unique ?

Amitabha Chattopadhyay  Centre for Cellular and Molecular Biology, Hyderabad, India 

E-mail: amit@ccmb.res.in  

2 G-protein Coupled Receptors Signaling:  Membrane Diffusion and Organization matter

Laurence Salomé   Institute of Pharmacology and Structural Biology, CNRS, France 

E-mail: laurence.salome@ipbs.fr

3 Nanoparticle Probes of Single Molecule Rotation (or Motion) on Cell Surfaces

George Barisas  Colorado State University Fort Collins, CO, U.S.A. 

E-mail:george.barisas@colostate.edu 

4 Organization of Membrane Proteins and Peptides using Multidimensional Microscopy

Andrew Clayton Swinburne University of Technology Centre for Micro-Photonics 

Victoria, Australia 

E-mail: aclayton@swin.edu.au

5 Probing Membrane Domain Heterogeneity with k-space Image Correlation Spectroscopy

Paul Wiseman Department of Chemistry McGill University Montreal, Quebec, Canada 

E-mail: paul.wiseman@mcgill.ca

6 Role of Membrane Domains for GPCR Functions

Evgeni Ponimaskin Cellular Neurophysiology Hannover Medical School Hannover, Germany 

E-mail: Ponimaskin.Evgeni@mh-hannover.de

7 Investigating the Dynamics and Organization of Membrane Proteins and Lipids using Imaging  Fluorescence Correlation Spectroscopy (Imaging FCS)

Thorsten Wohland  NUS Centre for Bio-Imaging Sciences, National University of Singapore, Singapore 

E-mail: twohland@nus.edu.sg

8 Combining MD Simulation and NMR Spectroscopy to Investigate the Structure and Dynamics of Membrane Constituents and Membrane Associated Proteins

9 Quantifying Membrane Protein Oligomerization by Single Molecule Methods

Gerhard J. Schuetz Institute of Applied Physics Vienna University of Technology Wien, Austria 

E-mail: schuetz@iap.tuwien.ac.at

10 Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation

Luís M. S. Loura  Centro de Química de Coimbra  University of Coimbra, Coimbra, Portugal 

E-mail: lloura@ff.uc.pt 

11 Organization and Dynamics of Archaeal Tetraether Lipid Membranes

Parkson Lee-Gau Chong  Department of Medical Genetics & Molecular Biochemistry  Temple University School of Medicine Philadelphia, Pennsylvania, U.S.A. 

E-mail: pchong02@temple.edu

12 Dynamics of Ion Channels in Membranes

M. K. Mathew  Laboratory of Membrane Biophysics National Centre for Biological Sciences, TIFR 

Bangalore, India 

E-mail: mathew@ncbs.res.in

13 Nanoscale Dynamics of Neurotransmitter Receptors and Lipid Platforms

Francisco J. Barrantes  Laboratory of Molecular Neurobiology Institute of Biomedical Research (BIOMED)  Pontifical Catholic University of Argentina  Ciudad Autónoma de Buenos Aires 

Argentina 

E-mail: rtfjb1@yahoo.com ; rtfjb1@criba.edu.ar

14 Role of Omega-3 Fatty Acids in Membrane Cholesterol Domain Formation under Disease Conditions

R. Preston Mason  Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston, MA, U.S.A.

E-mail: rpmason@elucidaresearch.com

15 Computer Simulation of Membrane Proteins
Carmen Domene, Department Chemistry, King's College, London, UK
E-mail: carmen.domene@kcl.ac.uk

16 GPCR Organization and Oligomerization: Role of Membrane Lipids

Amitabha Chattopadhyay (Co-author: Durba Sengupta) Centre for Cellular and Molecular Biology, 

Hyderabad, India 

E-mail: amit@ccmb.res.in