Preface xxiAcknowledgments xxiii1 Introduction to Medical Imaging 2Raymond M. Reilly1.1 Medical Imaging Procedures 21.2 Radiation Doses from Medical Imaging Procedures 41.3 Summary 8References 92 X-Ray, CT, and Mammography Technology 11Raymond M. Reilly2.1 Introduction 112.2 X-Rays 112.3 Radiography 152.4 Computed Tomography 162.5 Mammography 232.6 Summary 25References 26Additional Reading 263 Nuclear Medicine Imaging Technology 27Raymond M. Reilly3.1 Introduction 273.2 Scintillation Detectors 283.3 The Gamma Camera 313.4 Single Photon Emission Computed Tomography 373.5 Positron Emission Tomography 383.6 Multimodality Imaging - SPECT/CT, PET/CT, and PET/MR 413.7 Summary 42References 424 Radionuclide Production and Radiopharmaceuticals 46Noor Al-saden and Raymond M. Reilly4.1 Introduction 464.2 Production of Radionuclides 474.3 Radiopharmaceutical Preparation and Supply 574.4 Radiopharmaceuticals for Cardiac Imaging 584.5 Radiopharmaceuticals for Tumor Imaging 634.6 Radiopharmaceuticals for Brain/CNS Imaging 704.7 Radiopharmaceuticals for Renal Imaging 744.8 Radiopharmaceuticals for Hepatobiliary Imaging 764.9 Radiopharmaceuticals for Bone Imaging 774.10 Radiopharmaceuticals for Lung Imaging 794.11 Radiopharmaceuticals for Thyroid/Parathyroid Imaging 804.12 Radiopharmaceuticals for Imaging Infection/Inflammation 834.14 Summary 85Reference 85Additional Reading 855 Magnetic Resonance Imaging (MRI) Technology 87Raymond M. Reilly5.1 Introduction 875.2 Principles of MRI 875.3 Components of the MRI System 985.4 MRI Safety Considerations 1005.5 MRI Contrast Agents 1025.6 Summary 104References 105Additional Reading 1056 Ultrasound Imaging Technology 107Raymond M. Reilly6.1 Principles of Ultrasound Imaging 1076.2 Doppler US 1116.3 US Contrast Agents 1126.4 Summary 113References 113Additional Reading 1137 Cardiac Imaging 117Laura Jimenez-Juan, Shaheeda Ahmed, and Katherine Zukotynski7.1 Introduction 1177.2 Cardiovascular Magnetic Resonance Imaging (CMR) 1177.3 Cardiovascular MRI Techniques 1187.4 Echocardiography 1297.5 Nuclear Cardiology 1337.6 Summary 140References 1408 Lung Imaging 146Anastasia Oikonomou8.1 Introduction 1468.2 Chest Radiograph - Projections 1468.3 Normal Findings in a Chest X-Ray 1488.4 Normal Findings in a Chest CT 1558.5 Pneumonia 1588.6 Tuberculosis 1598.7 Chronic Obstructive Pulmonary Disease 1638.8 Pleural Effusion 1678.9 Pneumothorax 1698.10 Pulmonary Embolism 1708.11 Solitary Pulmonary Nodule 1728.12 Lung Cancer 1768.13 Summary 178References 1809 Breast Imaging 186Hemi Dua and Jagbir Khinda9.1 Introduction 1869.2 Risk Factors for Breast Cancer 1869.3 Guidelines for Breast Cancer Screening 1879.4 Breast Anatomy 1899.5 Imaging Techniques 1919.6 Mammography 1919.7 Ultrasound Imaging 1979.8 Breast MRI 1989.9 PEM and Breast-Specific Gamma Camera Imaging 2029.10 Contrast-Enhanced Spectral Mammography 2029.11 The ABCs of Breast Imaging - Image Interpretation 2039.12 BI-RADS Assessment Categories 2099.13 Image-Guided Breast Intervention 2099.14 Extramammary Staging 2199.15 Breast Lymphoscintigraphy 2209.16 Summary 220References 22010 Endocrine Gland Imaging 225Katerina Mastrocostas, Kim May Lam, Shereen Ezzat, and Sangeet Ghai10.1 Introduction 22510.2 The Thyroid Gland 22510.3 Thyroid Hormone Diseases 22710.4 Thyroid Cancer 24010.5 The Parathyroid Glands 24410.6 The Adrenal Glands 24910.7 Mass Lesions of the Adrenal Cortex 25010.8 Mass Lesions of the Adrenal Medulla 25310.9 Other Neuroendocrine Diseases 25510.10 Summary 259Additional Reading 26011 Abdominal Imaging 264Vivek Singh and Chirag Patel11.1 Introduction 26411.2 Surgical Sieve 26511.3 Peritoneum/Mesentery 26511.4 Acute Peritoneal Pathologies 26611.5 Gastrointestinal Tract 27011.6 Inflammatory Bowel Disease 27911.7 Colorectal Adenocarcinoma 28211.8 Hepatic System 28711.9 Diffuse Hepatic Disease 28911.10 Focal Hepatic Disease 29211.11 Biliary Tract 30011.12 Gallbladder 30111.13 Bile Ducts 30411.14 Pancreas 30611.15 Spleen/Lymph Nodes 31311.16 Summary 316Reference 317Additional Reading 31712 Genitourinary Tract Imaging 320Sarah Johnson12.1 Introduction 32012.2 GU System Imaging Modalities 32112.3 Evaluation of the Kidneys and Collecting Systems 32812.4 Bladder and Urethra 34312.5 Testicles 34512.6 Prostate 34812.7 Female Genitourinary Tract 35012.8 Pediatric Genitourinary Tract 36012.9 Summary 364References 36413 Imaging of the Head, Neck, Spine, and Brain 371Laila Alshafai, Eugene Yu, and Sylvain Houle13.1 Introduction 37113.2 Imaging the Skull and Brain 37213.4 Imaging the Head and Neck 39013.5 PET and SPECT Neuroimaging 39613.6 Summary 401References 40114 Musculoskeletal Imaging 404Rakesh Mohankumar and Ali Naraghi14.1 Introduction 40414.2 Plain Radiography (X-rays) 40414.3 Computed Tomography 40814.4 Magnetic Resonance Imaging 41114.5 Ultrasound 41314.6 Applications of Musculoskeletal Imaging 41514.7 Summary 435Additional Reading 43515 Molecular Imaging with Positron Emission Tomography 439Ur Metser, Noam Tau, and Amit Singnurkar15.1 Introduction 43915.2 PET Probes Including 18F-FDG 44015.3 18F-FDG PET in Oncology 44215.4 18F-FDG PET in Non-Oncology Indications 45315.5 Overview of Other PET Radiopharmaceuticals 46015.6 Multimodal Imaging - PET/CT Versus PET/MR 46815.7 Summary 470References 470Index 485
Raymond M. Reilly, PhD, is a Professor and Director of the Centre for Pharmaceutical Oncology in the Leslie Dan Faculty of Pharmacy at the University of Toronto. He teaches the elective course "Medical Imaging for Pharmacists" for third year pharmacy students. Dr. Reilly has published 159 full research papers, 11 books or book chapters, and 137 abstracts. His areas of research are imaging and treatment of cancer using radiopharmaceuticals. His first book, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer, won first prize in the oncology category at the British Medical Association book awards in 2011.