Mechanotransduction: Volume 126

ISBN-13: 9780123946249 / Angielski / Twarda / 2014 / 384 str.

Adam J. Engler

Opis

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction.

• Provides a unique combination of perspectives from biologists and engineers
• Engaging to people of many training backgrounds

Recenzje

Praise for the series:"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

Spis treści

Subcellular tools for activating and measuring mechanotransductive signaling

1. The Detection and Role of Molecular Tension in Focal Adhesion DynamicsBrenton D. Hoffman2. Single Cell Imaging of Mechanotransduction in Endothelial CellsShaoying Lu and Yingxiao Wang

Focal adhesions as sensors

3. Focal Adhesions as SensorsJean-Cheng Kuo4. Focal Adhesions as SensorsWolfgang H. Goldmann5. Mechanical Cues Direct Focal Adhesion DynamicsKristina Haase, Zeinab Al-Rekabi and Andrew E. Pelling6. Molecular Mechanisms Underlying the Force-Dependent Regulation of Actin-to-ECM Linkage at the Focal AdhesionsHiroaki Hirata, Masahiro Sokabe and Chwee Teck Lim

Nuclear Mechanisms of Sensing

7. The Cellular Mastermind(?) - Mechanotransduction and the NucleusAshley Kaminski, Gregory R. Fedorchak and Jan Lammerding8. Nuclear Forces and Cell Mechano-SensingSamer Alam, David B. Lovett, Richard B. Dickinson, Kyle J. Roux and Tanmay P. Lele

Mechano-sensing in Stem Cells

9. From Stem Cells to Cardiomyocytes: The Role of Forces in Cardiac Maturation, Aging, and DiseaseGaurav Kaushik and Adam J. Engler10. Matrix Regulation of Tumor-Initiating CellsSophie Y. Wong and Sanjay Kumar11. Biomaterials Approaches in Stem Cell MechanobiologyNikolche Gjorevski and Matthias Lutolf

Multi-cellular Sensing

12. Mechanotransduction in C. elegans Morphogenesis and Tissue FunctionErin J. Cram13. Mechanical Force Sensing in TissuesSoline Chanet and Adam C. Martin

O autorze

Adam J. Engler is a professor of Bioengineering at UC San Diego and is affiliated with the Material Science and Biomedical Sciences Programs. He also is a resident scientist at the Sanford Consortium for Regenerative Medicine. His research focuses on how physical properties of the niche influence stem cell function and misregulate muscle function and heart performance during disease and aging. Dr. Engler earned his B.S.E. degree in bioengineering and a Ph.D. in mechanical engineering and applied mechanics at the University of Pennsylvania in the lab of Dr. Dennis Discher. Dr. Engler then moved to Princeton University's Department of Molecular Biology as a Postdoctoral Research Fellow in the lab of Dr. Jean Schwarzbauer where his work was funded by the National Cancer Institute. Dr. Engler is the 2008 recipient of the Rupert Timpl and Rita Schaffer Young Investigator Awards from the International Society for Matrix Biology and the Biomedical Engineering Society, respectively. He is also a 2009 NIH Innovator Award recipient, a 2010 Young Investigator Awardee from the Human Frontier Science Program, and a 2013 IDEA Awardee from the Dept. of Defense. Sanjay Kumar is Associate Professor of Bioengineering at UC Berkeley and Faculty Scientist at Lawrence Berkeley National Laboratory. He also currently serves as Chair of the UC Berkeley & UCSF Graduate Program in Bioengineering and Faculty Director of the UC Berkeley & UCSF Master of Translational Medicine Program. He earned a B.S. in chemical engineering (1996) from the University of Minnesota and then moved on to Johns Hopkins University, where he earned an M.D. (2003) and a Ph.D. in molecular biophysics (2003) as a fellow of the NIH Medical Scientist Training Program. From 2003-2005, he served as an NIH research fellow at Children's Hospital Boston and Harvard Medical School. Since joining the UC Berkeley faculty in 2005, Dr. Kumar has been fortunate to receive a number of honors, including the Presidential Early Career Award for Scientists and Engineers (PECASE), The NIH Director's New Innovator Award, The Arnold and Mabel Beckman Young Investigator Award, the NSF CAREER Award, the Hellman Family Faculty Fund Award, and the Stem Cells Young Investigator Award. He also received awards by student vote for Excellence in Graduate Advising and Outstanding Teaching, and he has served as a Presidential Chair Teaching Fellow. Work in his laboratory has been sponsored by grants and fellowships from NIH, NSF, DOD, AHA, CRCC, LBNL, The Beckman Foundation, and the University of California.