Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition

ISBN-13: 9781138473621 / Angielski / Twarda / 2017

Urs A. Boelsterli

Opis

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk

Recenzje

“This book is specialized to one particular area of toxicology, the mechanisms by which topic substances work. It focuses on the general principles that link xenobiotic-induced toxicity with molecular pathways underlying those toxic effects. In includes many examples using drugs, environmental pollutants and other chemicals. … each chapter has been updated and new chapters added. … this book is intended for the advanced undergraduate of beginning graduate level student. … it might also be used by specialists in other areas needing information about the subject. … there is an extensive bibliography of papers at the end of each chapter.”
— In Books-On-Line, Web. 6207884-1433, May 2007

Spis treści

Introduction, Types of Toxic Responses, Organ-Selective Toxicity, Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics,  Bioactivation of Xenobiotics to Reactive Metabolites, Xenobiotic-Induced Oxidative Stress: Cell Injury, Signaling, and Gene Regulation, Disruption of Cellular Calcium Homeostasis, Mechanisms of Necrotic and Apoptotic Cell Death,  Impairment of Cell Proliferation and Tissue Repair, Covalent Binding of Reactive Metabolites to Cellular Macromolecules, Immune Mechanisms, Cytokine-Mediated Toxicity, Specific Inactivation of Enzymes and Other Proteins, Interactions of Xenobiotics with Ion Transporters, Nuclear Receptor-Mediated Toxicity, Activation or Disruption of Cellular Signal Transduction by Xenobiotics, Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity, Novel Mechanisms Derived from Systems Toxicology, Index

O autorze

Urs A. Boelsterli