Mechanisms of Drug Resistance in Cancer Therapy

ISBN-13: 9783030105068 / Angielski / Twarda / 2019 / 297 str.

Mario Mandala; Emanuela Romano

Spis treści

1. Molecular and Pharmacological Mechanisms of Drug Resistance: An Evolving Paradigm.- 2. Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival.- 3. Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies.- 4. Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer.- 5. Mechanisms of Drug Resistance in Melanoma.- 6. Mechanisms of Resistance to Immune Checkpoint Antibodies.- 7. Immunotolerance as a Mechanism of Resistance to Targeted Therapies in Melanoma.- 8. Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer.- 9. Targeting DNA repair.- 10. Resistance to Hormonal Therapy in Prostate Cancer.- 11. Mechanism of Resistance in Gastrointestinal Stromal Tumors.- 12. Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.- 13. Mechanisms of Resistance to Targeted Therapies in Chronic Myeloid Leukemia.- 14. Mechanisms of Resistance in Multiple Myeloma.- 15. Cancer Evolution as the New Frontier of Precision.