Mechanisms and Concepts in Toxicology

ISBN-13: 9780748404131 / Angielski / Twarda / 1996 / 254 str.

W. Norman Aldridge;Aldridge; Aldridge Norman Aldridge

Opis

This text focuses on research procedures in toxicology, aiming to illustrate toxicological concepts and types of toxicity from a mechanistic point of view. Mechanistic research in toxicology leads not only to a greater understanding of the biology involved, but also the means to design substances with selectivity between species and minimal undesirable side effects. Examples of chemical intoxicants are used to illustrate mechanisms in each stage of developing toxicity.

Spis treści

Scope of Toxicology

Stages in the Induction of Toxicity

Kinetics and End-points

Acute and Chronic Intoxication

Delivery of Intoxicant: Decrease in Delivery to the Target

Delivery of Intoxicant: Bioactivation and Increase in Delivery to the Target

Initiating Reactions with Targets

Biological Consequences of Initiating Reactions with Targets

Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds

Selective Toxicity, Animal Experimentation and In Vitro Methods

Biomonitoring

Epidemiology

Environmental and Ecotoxicology

Reflections, Research and Risk

O autorze

Aldridge, W. Norman