Mass Spectrometry in Drug Metabolism and Pharmacokinetics

ISBN-13: 9780471751588 / Angielski / Twarda / 2008 / 408 str.

Ragu Ramanathan

Opis

This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.

Recenzje

“All in all, the book delivers on its promises to introduce and review the current art of mass spectrometry for the related disciplines of drug metabolism and pharmacokinetics. I highly recommend it.” ( JACS Book Reviews, June 2009)

“In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics.” (Doody′s, April 2009)

"Mass Spectrometry in Drug Metabolism and Pharmacokinetics is a valuable and interesting resource for a broad readership, including scientists starting to work in DMPK as well as undergraduate and graduate students getting involved in drug discovery and characterization by means of MS. A wealth of information is provided and all of the contributing authors have done an excellent job in explaining and outlining particular aspects of MS–based tools in DMPK ... the book is highly recommended reading." (Journal of the American Society for Mass Spectrometry, March 2009)

Spis treści

Preface vii

About the Editor ix

Contributors xi

1. Evolving Role of Mass Spectrometry in Drug Discovery and Development 1
Dil M. Ramanathan and Richard M. LeLacheur

2. Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications 87
Ayman El–Kattan, Chris Holliman, and Lucinda H. Cohen

3. Quadrupole, Triple–Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis 123
Elliott B. Jones

4. Applications of Quadrupole Time–of–Flight Mass Spectrometry in Reactive Metabolite Screening 159
Jose M. Castro–Perez

5. Changing Role of FTMS in Drug Metabolism 191
Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders

6. High–Resolution LC–MS–Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection 223
Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L. Ray

7. Applications of High–Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies 253
Wing W. Lam, Cho–Ming Loi, Angus Nedderman, and Don Walker

8. Online Electrochemical–LC–MS Techniques for Profiling and Characterizing Metabolites and Degradants 275
Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N. Acworth

9. LC–MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N–Oxide, and Hydroxylated Analogs of Desloratadine 295
Natalia A. Penner, Joanna Zgoda–Pols, Ragu Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton

10. Turbulent–Flow LC–MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification 311
Joseph L. Herman and Joseph M. Di Bussolo

11. Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules 341
Jason S. Gobey, John Janiszewski, and Mark J. Cole

12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals 359
Yunsheng Hsieh and Walter A. Korfmacher

Index 383

O autorze

Ragu Ramanathan received a B.Sc. in Chemistry from the University of Southern Mississippi and a Ph.D. in Physical Chemistry/Mass Spectrometry from the University of Florida. His graduate research focused on coupling of electrospray ionization (ESI) to Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. After spending three years as a postdoctoral research fellow with Professor Michael L. Gross at the Washington University, St. Louis, Missouri, Dr. Ramanathan managed the Center for Advanced Mass Spectrometry at the Analytical Bio–Chemistry Laboratories, Columbia, Missouri. In 1998, Dr. Ramanathan joined Schering–Plough Research Institute’s (SPRI) Drug Metabolism and Pharmacokinetics (DMPK) Department and completed his tenure as a senior principal scientist in 2008. While at SPRI, Dr. Ramanathan was involved in the application of LC–MS for profiling and characterization of metabolites of drug candidates in the preclinical development and clinical stages. Dr. Ramanathan was with Pfizer Global Research and Development from 1999 to 2002 as a group leader of the Ann Arbor site biotransformation group. Dr. Ramanathan is currently an associate director at the Bristol–Myers Squibb, Co. and is responsible for elucidating biotransformation pathways of development drug candidates. Dr. Ramanathan’s accomplishments include 35 peer–reviewed papers, 10 book chapters, and over 60 oral/poster presentations. He also served as a chairperson for the North Jersey ACS Mass Spectrometry Discussion Group and as a chairman for DMPK sessions of the American Society for Mass Spectrometry and Eastern Analytical Symposium meetings.

Blurb

Advanced mass spectrometry techniques to support your drug discovery and development research

Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You′ll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.

Logically organized, Mass Spectrometry in Drug Metabolism and Pharmacokinetics starts off with an overview of the role of mass spectrometry in drug discovery and development. It then shows you how to perform routine applications before introducing you to sophisticated tools and techniques for solving complex drug metabolism and pharmacokinetics problems. Throughout the book, the main focus is on the use of LC–MS and MALDI–MS.

Each chapter has been written by one or more leading experts who share their own first–hand laboratory experience. You′ll gain a wealth of tips for performing successful analyses as well as avoiding common pitfalls. Moreover, the book is packed with features that help you grasp new concepts quickly and put your knowledge into practice, including:

• Figures and illustrations to help you understand how to perform specific techniques and applications

• Charts and tables that serve as quick summaries and reference guides

• Coverage of the latest tested–and–proven techniques

• References leading to the primary literature in the field

Carefully edited to ensure thoroughness and a uniform standard of quality, this book is sure to help you advance your own important drug research efforts.