Mammalian Trp Channels as Molecular Targets

ISBN-13: 9780470862544 / Angielski / Twarda / 2004 / 288 str.

Novartis Foundation Symposium;Novartis Foundation Symposium

Opis

This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.

Spis treści

Chair′s Introduction (J. Putney).

Molecular genetics of Drosophila TRP channels (C. Montell).

Mammalian TRPC channnel subunit assembly (W. Schilling and M. Goel).

TRPC channel interactions with calmodulin and IP₃ receptors (M. Zhu & J. Tang).

Plasma membrane localizations of TRPC channels: role of caveolar lipid rafts (I. Ambudkar, et al.).

Assembly and gating of TRPC channels in signalling microdomains (P. Delmas).

General discussion I.

Activation, subunit composition and physiological relevance of DAG–sensitive TRPC  proteins (T. Gudermann, et al.).

Signalling mechanisms for TRPC3 channels (J. Putney, et al.).

Diversity of TRP channel activation (B. Nilius and T. Voets).

General discussion II.

Regulation of Drosophila TRP channels by lipid messengers (R. Hardie).

Control of TRPC and store–operated channels by protein kinase C (K. Venkatachalam, et al.).

TRPC4 and TRPC4 deficient mice (M. Freichel, et al.).

TRP channels as drug targets (S. Li, et al.).

Role of TRP channels in oxidative stress (K. Groschner, et al.).

Distribution of TRPC channels in a visceral sensory pathway (M. Buniel, et al.).

Emerging roles of TRPM channels (A. Fleig and R. Penner).

Final discussion.

Index of contributors.

Subject index.

Blurb

Transient receptor potential (TRP) genes were originally identified as encoding critical components of phototransduction in Drosophila. Since the discovery of the first mammalian transient receptor potential channel (TRPC), more than 20 mammalian homologues have been reported. These ion channel proteins are widely distributed in tissues and appear to play a fundamental role in cell signalling, growth and death.

There are two major subfamilies of TRP channels. The TRPV channels include the VR1 vanilloid receptor, epithelial Ca²⁺ channels and OTRPC4, a channel that appears to be regulated by changes in osmolarity. Their functions may range from sensory transduction in nerves to Ca²⁺ transport in the gastrointestinal tract and renal tubule. The TRPM channels, which are the largest proteins in the TRP family, include the founding member, melastatin, and a novel bifunctional channel enzyme, TRP–PLIK.

This book brings together contributions from key investigators in the area of TRP channels. It covers the structure, function and regulation of mammalian TRP channels and of mechanisms of signal transduction. The discussions highlight future studies towards a better understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states, and their potential use as molecular targets for novel therapeutic agents.

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