Macromolecular Protein Complexes: Structure and Function

ISBN-13: 9783319835303 / Angielski / Miękka / 2018 / 572 str.

J. Robin Harris; Jon Marles-Wright

Spis treści

1 Structure and function of the stressosome signalling hub
Jan Pané-Farré, Maureen B. Quin, Richard J. Lewis, Jon Marles-Wright

2 The Canonical Inflammasome - a macromolecular complex driving inflammation
Tom P. Monie

3 The Ferritin superfamily
Alejandro Yévenes

4 Antibody Recognition of Immunodominant Vaccinia Virus Envelope Proteins
Dirk M. Zajonc

5 The Peroxiredoxin Family: An Unfolding Story
Zhenbo Cao and J. Gordon Lindsay

6 α2-Macroglobulins: structure and function
Irene Garcia-Ferrer, Aniebrys Marrero, F. Xavier Gomis-Rüth, Theodoros Goulas

7 The Structure and Function of the PRMT5:MEP50 Complex
Stephen Antonysamy

8 Symmetry-Directed Design of Protein Cages and Protein Lattices and their Applications
Aaron Sciore and E. Neil G. Marsh

9 STRUCTURE AND FUNCTION RNA POLYMERASES AND THE TRANSCRIPTION MACHINERIES
Joachim Griesenbeck, Herbert Tschochner and Dina Grohmann

10 Dihydrodipicolinate synthase: Structure, dynamics, function, and evolution.
F. Grant Pearce, André O. Hudson, Kerry Loomes, Renwick C.J. Dobson

11 Pyruvate Carboxylase, Structure and Function
Mikel Valle

12 Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction
Henry C. Nguyen, Wei Wang, and Yong Xiong

13 The Ccr4-Not complex: Architecture and structural insights
Martine A. Collart and Olesya O. Panasenko

14 Higher-order structure in bacterial VapBC toxin-antitoxin complexes
Kirstine L. Bendtsen and Ditlev E. Brodersen

15 D-glyceraldehyde-3-Phosphate Dehydrogenase Structure and Function
Michael R. White and Elsa D. Garcin

16 Protein Complexes in the Nucleus: the control of chromosome segregation
Victor M. Bolanos-Garcia

17 GroEL and the GroEL-GroES Complex
Noriyuki Ishii

18 The Aminoacyl-tRNA Synthetase Complex
Marc Mirande

19 Apoptosome: the caspase-activating machine Mengying Zhou, Qi Hu, and Yigong Shi

20 The Pyruvate Dehydrogenase Complex and Related Assemblies in Health and Disease
Olwyn Byron and J. Gordon Lindsay

21 Type III CRISPR-Cas Systems: a structural perspective
Laura Spagnolo

22 Structure and assembly of clathrin cages
Mary Halebian, Kyle Morris, Corinne Smith

Index

Blurb

This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study.

The biological significance of these structural studies is emphasised throughout the book. The diversity of the material included here indicates the breadth of this field and the tremendous progress that has been made in recent years.

The book is directed primarily to advanced students and researchers in structural biology, and others in the biochemical sciences. It will be supplemented by other related books within the Subcellular Biochemistry series. One of the Editors (JM-W) is actively involved in structural biology and the other (JRH), as a retired academic and the Series Editor of Subcellular Biochemistry, has long experience at editing multi-author books.